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TXK
Gene Name
TXK tyrosine kinase
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Regulatory Region DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
Non-membrane Spanning Protein Tyrosine Kinase Activity
Receptor Binding
Protein Binding
ATP Binding
Biological Process
Cytokine Production
NK T Cell Differentiation
Adaptive Immune Response
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Activation Of Phospholipase C Activity
T Cell Differentiation
Interferon-gamma Production
Interleukin-4 Production
Positive Regulation Of Interferon-gamma Production
Peptidyl-tyrosine Autophosphorylation
Regulation Of Cell Proliferation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Protein Autophosphorylation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways
Fc epsilon receptor (FCERI) signaling
FCERI mediated Ca+2 mobilization
Innate Immune System
Drugs
Diseases
GWAS
Crohn's disease (
23128233
)
Protein-protein Interactions
10 interactors:
CCR5
CTLA4
ERBB2
ERBB3
FYN
LCP2
NELFCD
SH2D2A
SRC
YTHDC1
Entrez ID
7294
HPRD ID
02505
Ensembl ID
ENSG00000074966
Uniprot IDs
P42681
PDB IDs
2DM0
Enriched GO Terms of Interacting Partners
?
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Fc Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Immune Response
Fibroblast Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Negative Regulation Of Cell Adhesion
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Wound Healing
Regulation Of Cell Adhesion
Cell Surface Receptor Signaling Pathway
Peptidyl-tyrosine Phosphorylation
T Cell Costimulation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of T Cell Activation
Regulation Of Immune System Process
Immune System Process
Response To Wounding
Defense Response
Cellular Response To Platelet-derived Growth Factor Stimulus
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Innate Immune Response
Response To Platelet-derived Growth Factor
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Phosphatidylinositol-mediated Signaling
Antigen Receptor-mediated Signaling Pathway
Regulation Of Cell Activation
Phosphatidylinositol 3-kinase Signaling
Viral Process
Platelet Activation
Cellular Response To Growth Factor Stimulus
Protein Autophosphorylation
Response To Growth Factor
Chemotaxis
Positive Regulation Of T Cell Activation
Positive Regulation Of Signal Transduction
Negative Regulation Of T Cell Differentiation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Immune Response
Leukocyte Migration
Tagcloud
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abl
abundant
acting
bcr
bmx
brdg1
btk
constitute
docking
downstream
effectors
feature
feedback
homology
integrins
itk
lyn
participate
ph
pleckstrin
proline
ptks
pyk2
ramos
sh2
syk
tec
termed
triggered