TXK and CTLA4

Number of citations of the paper that reports this interaction (PMID 9813138)
7

Data Source:
HPRD (in vitro, in vivo)

		TXK	CTLA4
Gene Name		TXK tyrosine kinase	cytotoxic T-lymphocyte-associated protein 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	Protein Binding
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity T Cell Differentiation Interferon-gamma Production Interleukin-4 Production Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway	Immune Response Cellular Response To DNA Damage Stimulus Negative Regulation Of B Cell Proliferation T Cell Costimulation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Immune Response B Cell Receptor Signaling Pathway
Pathways		Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System	Costimulation by the CD28 family CTLA4 inhibitory signaling Adaptive Immune System
Drugs			Alpha-D-Mannose
Diseases
GWAS		Crohn's disease ( 23128233)	Alopecia areata ( 20596022) Celiac disease ( 20190752) Graves' disease ( 21841780) Hypothyroidism ( 22493691) Rheumatoid arthritis ( 20453842 19503088) Type 1 diabetes ( 19430480 18978792) Type 1 diabetes autoantibodies ( 21829393)
Protein-Protein Interactions		10 interactors: CCR5 CTLA4 ERBB2 ERBB3 FYN LCP2 NELFCD SH2D2A SRC YTHDC1	14 interactors: AP1M1 AP2M1 CD80 CD86 FYN JAK2 LCK LYN PIK3R1 PPP2R5A PTPN11 STAT5A STAT5B TXK
Entrez ID		7294	1493
HPRD ID		02505	00474
Ensembl ID		ENSG00000074966	ENSG00000163599
Uniprot IDs		P42681	P16410
PDB IDs		2DM0	1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Immune System Process Response To Wounding Defense Response Cellular Response To Platelet-derived Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Innate Immune Response Response To Platelet-derived Growth Factor Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Activation Phosphatidylinositol 3-kinase Signaling Viral Process Platelet Activation Cellular Response To Growth Factor Stimulus Protein Autophosphorylation Response To Growth Factor Chemotaxis Positive Regulation Of T Cell Activation Positive Regulation Of Signal Transduction Negative Regulation Of T Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune Response Leukocyte Migration	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Activation T Cell Costimulation Regulation Of T Cell Activation Regulation Of Immune Response Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Immune System Process Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Growth Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Peptide Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Hemopoiesis Positive Regulation Of Immune Response Neurotrophin TRK Receptor Signaling Pathway Lymphocyte Activation Peptidyl-tyrosine Autophosphorylation Cell Activation Response To Growth Hormone Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune System Development Response To Peptide Hormone Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Response To Peptide T Cell Aggregation Fc Receptor Signaling Pathway T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Phosphatidylinositol-mediated Signaling Regulation Of Cytokine Production Leukocyte Cell-cell Adhesion Viral Process Cellular Response To Organic Substance
Tagcloud ?		abl abundant acting bcr bmx brdg1 btk constitute docking downstream effectors feature feedback homology integrins itk lyn participate ph pleckstrin proline ptks pyk2 ramos sh2 syk tec termed triggered	airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation costimulatory engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr
Tagcloud (Difference) ?		abl abundant acting bcr bmx brdg1 btk constitute docking downstream effectors feature feedback homology integrins itk lyn participate ph pleckstrin proline ptks pyk2 ramos sh2 syk tec termed triggered	airway allergic asthma b7 bal blocking bronchoalveolar cd28 challenge challenges costimulation costimulatory engagement eosinophils eu hyperresponsiveness ige igg immunosuppressive infiltration inhalation lavage lymphocyte methacholine ovalbumin parabronchial sensitized tcr
Tagcloud (Intersection) ?