TXK and IKZF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TXK	IKZF4
Description		TXK tyrosine kinase	IKAROS family zinc finger 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Protein Phosphorylation Regulation Of Gene Expression Positive Regulation Of Type II Interferon Production Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Type II Interferon-mediated Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization
Pathways		FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252 32888494)	Age at first birth ( 34211149) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Alopecia areata ( 20596022 25608926) Anorexia nervosa ( 28494655) Asthma ( 32700739 31959851 31619474 21804548) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune traits (pleiotropy) ( 30572963) Brain morphology (MOSTest) ( 32665545) Cognitive ability (MTAG) ( 29186694) Cognitive function ( 25644384) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil percentage of granulocytes ( 27863252) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 1 diabetes ( 21829393 25751624 18198356) Vitiligo ( 27723757 22561518)
Interacting Genes		38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835	20 interacting genes: CDC7 CHD4 CSNK1D FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 MCRS1 MOB1A MOB3C NFKBIA NRG1 SIN3A SIN3B TCAF1 TCEA2 TXK
Entrez ID		7294	64375
HPRD ID		02505	05874
Ensembl ID		ENSG00000074966	ENSG00000123411
Uniprot IDs		P42681	F8VPL6 Q9H2S9
PDB IDs		2DM0	2MA7
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Phosphotyrosine Residue Binding ErbB-3 Class Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Intracellular Signal Transduction Basal Plasma Membrane Leukocyte Activation Ephrin Receptor Binding Positive Regulation Of Phosphorylation Protein Kinase Activity Cell Activation Signal Transduction Negative Regulation Of Immune System Process Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Ephrin Receptor Signaling Pathway Receptor Complex ERBB3:ERBB2 Complex Peptidyl-tyrosine Phosphorylation T Cell Activation Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Kinase Activity Immune System Process Regulation Of Cell Adhesion Schwann Cell Development Regulation Of Cell Activation Leukocyte Migration Epidermal Growth Factor Receptor Activity Positive Regulation Of Protein Phosphorylation Neuregulin Receptor Activity Regulation Of MAPK Cascade Cell Motility Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Scaffold Protein Binding Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Migration	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Sin3-type Complex Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II NF-kappaB Binding Histone Deacetylase Binding Cellular Response To Dopamine Negative Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Zinc Ion Binding NuRD Complex DNA Recombination Protein-containing Complex Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Positive Regulation Of Macromolecule Metabolic Process Response To Catecholamine Chromatin Organization Regulation Of Cell Fate Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle G2/M Phase Transition Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Locomotion
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