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TXK and ERBB3
Number of citations of the paper that reports this interaction (PubMedID
22973453
)
55
Data Source:
BioGRID
(pull down, unspecified method)
TXK
ERBB3
Description
TXK tyrosine kinase
erb-b2 receptor tyrosine kinase 3
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Extracellular Region
Extracellular Space
Plasma Membrane
Basal Plasma Membrane
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
ERBB3:ERBB2 Complex
Receptor Complex
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Growth Factor Binding
Protein Tyrosine Kinase Activator Activity
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
Neuregulin Receptor Activity
Neuregulin Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Biological Process
Positive Regulation Of Cytokine Production
Adaptive Immune Response
Immune System Process
Protein Phosphorylation
Regulation Of Gene Expression
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
T Cell Receptor Signaling Pathway
Positive Regulation Of Type II Interferon-mediated Signaling Pathway
Endocardial Cushion Development
Negative Regulation Of Cell Adhesion
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Peripheral Nervous System Development
Heart Development
Negative Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Schwann Cell Differentiation
Schwann Cell Development
Cranial Nerve Development
Neuron Differentiation
ERBB2-ERBB3 Signaling Pathway
Wound Healing
Regulation Of Cell Population Proliferation
Myelination
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Secretion
Neuron Apoptotic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cardiac Muscle Tissue Development
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Motor Neuron Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Motor Neuron Apoptotic Process
Pathways
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Drugs
Fostamatinib
Zanubrutinib
Tucatinib
Diseases
Type I diabetes mellitus
Lethal congenital contractural syndrome (LCCS)
GWAS
Aspartate aminotransferase levels (
33547301
)
Crohn's disease (
23128233
)
Mean platelet volume (
32888494
)
Multiple sclerosis (
31604244
)
Platelet distribution width (
27863252
32888494
)
Age at first sexual intercourse (
34211149
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Alopecia areata (
25608926
)
Anorexia nervosa (
28494655
)
Asthma (
31959851
31619474
30929738
)
Asthma (adult onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Autoimmune thyroid disease (
32581359
)
Body mass index (
32700739
)
Brain morphology (MOSTest) (
32665545
)
Cognitive function (
25644384
)
Household income (MTAG) (
31844048
)
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Smoking initiation (
33082346
30617275
)
Type 1 diabetes (
17554300
18198356
18978792
19430480
21829393
30572963
17554260
)
Vitiligo (
22951725
)
Interacting Genes
38 interacting genes:
CBY2
CCDC33
CCR5
CLNK
CRK
CTLA4
DOK2
DUSP6
EFHC2
EGFR
ERBB2
ERBB3
ERBB4
FYN
GRB10
GRB2
HOMEZ
IKZF1
IKZF4
JRK
KIT
LCP2
MET
NCK2
NELFCD
PIK3R1
PRDM14
RBAK
SH2D2A
SOCS3
SOCS6
SRC
STAP2
TNS4
YTHDC1
ZNF587
ZNF792
ZNF835
196 interacting genes:
ABL1
ABL2
ACYP1
AGTR2
ALDOA
ATP5ME
BCAR3
BEND5
BLK
BLNK
BTK
CALM1
CD82
CDC25C
CDK5
CFL1
CHN2
CRK
CRKL
CSPG5
DAB1
DAPP1
DUSP14
DUSP18
DUSP19
DUSP21
DUSP29
DYRK1A
EGF
EGFR
EGR1
ENOPH1
ERBB2
ERBB4
ERG28
EYA4
EZR
FAM241B
FER
FES
FGFR1
FGR
FHL3
FKBP1A
FLNA
FLYWCH1
GABARAPL1
GABARAPL2
GRAP2
GRB2
GRB7
HCK
HDAC6
HINT1
HSH2D
HSPA1A
HSPA8
IL6ST
ILKAP
INPPL1
IRF2BP2
ITK
JAK2
JAK3
JUP
LAMTOR2
LBHD1
LCK
LCP2
LRRC7
LYN
MAP1B
MATK
MTMR1
MTMR10
MTMR2
MTMR6
MTMR8
MTMR9
MUC1
MUC4
MYCBP
MYCBP2
NCK1
NCK2
NDUFAB1
NEDD4
NRG1
NRG2
NSMCE1
ODF2L
PA2G4
PDGFRA
PFDN2
PFDN4
PHPT1
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
PPM1A
PPM1B
PPM1F
PPM1K
PPM1M
PRDX5
PRKACA
PRRG4
PSMA5
PTEN
PTGES3
PTK2
PTK2B
PTK6
PTPDC1
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRH
PTPRR
RALGAPA1
RASA1
RASA4
RGS4
RIN1
RNF41
RPN1
RTN4
RWDD2A
S100A10
SAP18
SELENOK
SF3B6
SH2B1
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SMIM20
SNAP91
SNCA
SNRPB2
SOCS2
SOCS3
SOCS5
SOCS6
SORL1
SOS1
SRC
SRPK2
STAP1
STYX
SYK
SYNM
TBCA
TCEA2
TEC
TMA7
TMEM134
TMEM14A
TMEM230
TNS1
TNS2
TNS3
TNS4
TPTE
TRIR
TVP23B
TXK
TXN
TXNL4A
VAV1
VAV2
VAV3
VTA1
WRNIP1
YES1
YWHAZ
ZAP70
ZNF207
ZNF532
Entrez ID
7294
2065
HPRD ID
02505
01820
Ensembl ID
ENSG00000074966
ENSG00000065361
Uniprot IDs
P42681
P21860
PDB IDs
2DM0
1M6B
2L9U
3KEX
3LMG
3P11
4LEO
4P59
4RIW
4RIX
4RIY
5CUS
5O4O
5O7P
6KBI
6OP9
7BHE
7BHF
7D85
7MN5
7MN6
7MN8
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
ERBB2 Signaling Pathway
Phosphotyrosine Residue Binding
ErbB-3 Class Receptor Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Intracellular Signal Transduction
Basal Plasma Membrane
Leukocyte Activation
Ephrin Receptor Binding
Positive Regulation Of Phosphorylation
Protein Kinase Activity
Cell Activation
Signal Transduction
Negative Regulation Of Immune System Process
Regulation Of Programmed Cell Death
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Ephrin Receptor Signaling Pathway
Receptor Complex
ERBB3:ERBB2 Complex
Peptidyl-tyrosine Phosphorylation
T Cell Activation
Protein Tyrosine Kinase Activator Activity
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Response To Growth Factor
Positive Regulation Of Phosphate Metabolic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lymphocyte Activation
Kinase Activity
Immune System Process
Regulation Of Cell Adhesion
Schwann Cell Development
Regulation Of Cell Activation
Leukocyte Migration
Epidermal Growth Factor Receptor Activity
Positive Regulation Of Protein Phosphorylation
Neuregulin Receptor Activity
Regulation Of MAPK Cascade
Cell Motility
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Scaffold Protein Binding
Antigen Receptor-mediated Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
Cell Migration
Phosphotyrosine Residue Binding
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Non-membrane Spanning Protein Tyrosine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Protein Tyrosine Kinase Activity
ERBB Signaling Pathway
Intracellular Signal Transduction
Phosphoprotein Phosphatase Activity
Regulation Of Signal Transduction
Cytosol
Regulation Of Signaling
Regulation Of Cell Communication
Epidermal Growth Factor Receptor Signaling Pathway
Signal Transduction
Phosphate-containing Compound Metabolic Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Intracellular Signal Transduction
Fc Receptor Signaling Pathway
Protein Tyrosine Phosphatase Activity
Dephosphorylation
Regulation Of Immune Response
Cell Activation
Leukocyte Activation
Cytoplasm
Antigen Receptor-mediated Signaling Pathway
Protein Phosphorylation
Protein Modification Process
Immune Response-activating Signaling Pathway
Regulation Of Cell Adhesion
Protein Kinase Activity
Positive Regulation Of Signal Transduction
Phosphorylation
Immune Response-regulating Signaling Pathway
Protein Dephosphorylation
Positive Regulation Of Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Cell Migration
Receptor Tyrosine Kinase Binding
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Immune Response
Lymphocyte Activation
Fc Receptor Mediated Stimulatory Signaling Pathway
B Cell Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of MAPK Cascade
Regulation Of Immune System Process
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Tagcloud (Difference)
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Tagcloud (Intersection)
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