TXK and SH2D2A

Number of citations of the paper that reports this interaction (PMID 10587356)
19

Data Source:
HPRD (two hybrid)

		TXK	SH2D2A
Gene Name		TXK tyrosine kinase	SH2 domain containing 2A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding
	Biological Process	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Phospholipase C Activity T Cell Differentiation Interferon-gamma Production Interleukin-4 Production Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Autophosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway	Angiogenesis Signal Transduction Cell Proliferation Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System	Signaling by VEGF VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Crohn's disease ( 23128233)
Protein-Protein Interactions		10 interactors: CCR5 CTLA4 ERBB2 ERBB3 FYN LCP2 NELFCD SH2D2A SRC YTHDC1	11 interactors: EGFR ERBB2 ITK KDR LCK MAP3K2 MAPK7 PLCG1 SYK TXK VCP
Entrez ID		7294	9047
HPRD ID		02505	05152
Ensembl ID		ENSG00000074966	ENSG00000027869
Uniprot IDs		P42681	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		2DM0
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Negative Regulation Of Cell Adhesion Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Immune System Process Response To Wounding Defense Response Cellular Response To Platelet-derived Growth Factor Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Innate Immune Response Response To Platelet-derived Growth Factor Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Phosphatidylinositol-mediated Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Activation Phosphatidylinositol 3-kinase Signaling Viral Process Platelet Activation Cellular Response To Growth Factor Stimulus Protein Autophosphorylation Response To Growth Factor Chemotaxis Positive Regulation Of T Cell Activation Positive Regulation Of Signal Transduction Negative Regulation Of T Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Immune Response Leukocyte Migration	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Protein Autophosphorylation Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Autophosphorylation Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Peptidyl-amino Acid Modification Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Protein Phosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Fc Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Signal Transduction By Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Cellular Metabolic Process Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Phosphorylation Activation Of Phospholipase C Activity Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Phosphate-containing Compound Metabolic Process Positive Regulation Of Phospholipase C Activity Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of MAPK Cascade Immune System Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Neurotrophin Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Signal Transduction Positive Regulation Of Hydrolase Activity Cellular Response To Growth Factor Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Response To Growth Factor Regulation Of Intracellular Signal Transduction
Tagcloud ?		abl abundant acting bcr bmx brdg1 btk constitute docking downstream effectors feature feedback homology integrins itk lyn participate ph pleckstrin proline ptks pyk2 ramos sh2 syk tec termed triggered	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?		abl abundant acting bcr bmx brdg1 btk constitute docking downstream effectors feature feedback homology integrins itk lyn participate ph pleckstrin proline ptks pyk2 ramos sh2 syk tec termed triggered	adaptors coimmunoprecipitated comprises dok1 epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?