TXK and DOK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TXK	DOK2
Description		TXK tyrosine kinase	docking protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Adaptive Immune Response Immune System Process Protein Phosphorylation Regulation Of Gene Expression Positive Regulation Of Type II Interferon Production Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Type II Interferon-mediated Signaling Pathway	Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction
Pathways		FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	Tie2 Signaling RET signaling
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 27863252 32888494)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Entorhinal cortical thickness ( 21116278) Lymphocyte count ( 32888494) Mean corpuscular volume ( 20139978) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neuropathic pain in type 2 diabetes ( 24974787) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 30206226) Platelet distribution width ( 32888494) Refractive error ( 32231278) Verbal declarative memory ( 25648963)
Interacting Genes		38 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TNS4 YTHDC1 ZNF587 ZNF792 ZNF835	22 interacting genes: ABL1 APPL1 CRK CRKL CSK DOK3 EGFR HCK IL4R INPP5D KIFBP LCK LYN NCK1 POT1 RASA1 RET SRC STAT3 TEK TXK YES1
Entrez ID		7294	9046
HPRD ID		02505	05411
Ensembl ID		ENSG00000074966	ENSG00000147443
Uniprot IDs		P42681	B4DKQ6 O60496
PDB IDs		2DM0	2D9W 2DLW
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Phosphotyrosine Residue Binding ErbB-3 Class Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Intracellular Signal Transduction Basal Plasma Membrane Leukocyte Activation Ephrin Receptor Binding Positive Regulation Of Phosphorylation Protein Kinase Activity Cell Activation Signal Transduction Negative Regulation Of Immune System Process Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Ephrin Receptor Signaling Pathway Receptor Complex ERBB3:ERBB2 Complex Peptidyl-tyrosine Phosphorylation T Cell Activation Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Response To Growth Factor Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Activation Kinase Activity Immune System Process Regulation Of Cell Adhesion Schwann Cell Development Regulation Of Cell Activation Leukocyte Migration Epidermal Growth Factor Receptor Activity Positive Regulation Of Protein Phosphorylation Neuregulin Receptor Activity Regulation Of MAPK Cascade Cell Motility Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Scaffold Protein Binding Antigen Receptor-mediated Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Cell Migration	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Immune Response-activating Signaling Pathway Positive Regulation Of Cell Adhesion Ephrin Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Fc-gamma Receptor Signaling Pathway Positive Regulation Of Immune Response Protein Kinase Activity Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Receptor Signaling Pathway Kinase Activity Fc Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Fc Receptor Mediated Stimulatory Signaling Pathway Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Leukocyte Migration Immune System Process Negative Regulation Of Immune System Process Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Activation Signaling Receptor Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Defense Response T Cell Costimulation Cell Migration Positive Regulation Of Cell-cell Adhesion Plasma Membrane Membrane Raft Negative Regulation Of Immune Response Regulation Of Lymphocyte Activation Regulation Of Cell Migration Cellular Developmental Process
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