C4BPA and LRP1

Number of citations: 0 (PubMedID 11705989)
Data Source: HPRD (in vitro, in vivo)

		C4BPA	LRP1
Name		complement component 4 binding protein alpha	LDL receptor related protein 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Blood Microparticle	Nucleus Nucleolus Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Endocytic Vesicle Membrane Receptor Complex Plasma Membrane Protein Complex
	Molecular Function	RNA Binding Protein Binding	Amyloid-beta Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Lipoprotein Particle Receptor Binding
	Biological Process	Immune System Process T Cell Mediated Immunity Complement Activation, Classical Pathway Response To Symbiotic Bacterium Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Immune Response Response To Other Organism Regulation Of Opsonization	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Lipid Transport Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Transport Apoptotic Cell Clearance Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of SMAD Protein Signal Transduction Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Amyloid-beta Clearance Regulation Of Extracellular Matrix Organization Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Regulation of Complement cascade	Scavenging of heme from plasma Retinoid metabolism and transport
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Von Willebrand factor human Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency	None
GWAS		Bell's palsy ( 33602968 ) C4b binding protein levels ( 20212171 ) Mean platelet volume ( 27863252 32888494 ) Platelet distribution width ( 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Venous thromboembolism ( 31420334 31676865 )	Abdominal aortic aneurysm ( 22055160 27899403 ) Adult asthma ( 30787307 ) Appendicular lean mass ( 33097823 ) Asthma ( 31959851 31619474 29273806 27182965 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Body mass index ( 28552196 ) Cervical artery dissection ( 25420145 ) Coronary artery disease ( 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) HDL cholesterol ( 20686565 24097068 ) HDL cholesterol levels ( 28334899 ) Headache ( 29397368 ) Height ( 31562340 ) Itch intensity from mosquito bite ( 28199695 ) Lung function (FEV1/FVC) ( 30804560 ) Medication use (anilides) ( 31015401 ) Medication use (antimigraine preparations) ( 31015401 ) Migraine ( 27322543 22683712 21666692 23793025 27182965 ) Migraine - clinic-based ( 23793025 ) Migraine without aura ( 23793025 27322543 ) Moyamoya disease ( 29273593 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pulse pressure ( 30578418 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 ) Spontaneous coronary artery dissection ( 32374345 32887874 ) Triglyceride levels ( 28334899 ) Triglycerides ( 25961943 24097068 20686565 )
Interacting Genes		11 interacting genes: APCS BMPR2 FXYD6 GIT2 GTF2I HSP90AA1 LBP LRP1 PROS1 SMARCD1 TXN	74 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CLU CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90AA1 HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NGF NOS1AP NTF3 NTF4 PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RBM11 RIC8B RNF10 SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		722	4035
HPRD ID		00403	00138
Ensembl ID		ENSG00000123838	ENSG00000123384
Uniprot IDs		P04003	Q07954 Q59FG2
PDB IDs		2A55 4B0F 5HYP 5HYT 5HYU 5HZP 5I0Q 8TCB 8TGT	1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
GO Terms Enriched among Interactors		Chaperone-mediated Protein Complex Assembly Regulation Of Multicellular Organismal Process Acute-phase Response Negative Regulation Of Wound Healing Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Negative Regulation Of Multicellular Organismal Process Acute Inflammatory Response Regulation Of SMAD Protein Signal Transduction Artery Morphogenesis Clathrin-coated Pit Protein Tyrosine Kinase Binding Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis CTP Binding DATP Binding Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Lipopolysaccharide Transport Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Regulation Of Transcytosis Apolipoprotein Receptor Activity Cellular Detoxification Of Hydrogen Peroxide Blood Vessel Morphogenesis Activin Receptor Activity, Type II Rho GDP-dissociation Inhibitor Binding Lipoprotein Particle Receptor Binding Detoxification Of Hydrogen Peroxide Negative Regulation Of Developmental Process Unfolded Protein Binding Regulation Of Lung Blood Pressure Positive Regulation Of Multicellular Organismal Process Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Nucleocytoplasmic Transport Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein-disulfide Reductase [NAD(P)H] Activity Blood Microparticle	Signaling Receptor Binding Extracellular Space Extracellular Region Low-density Lipoprotein Particle Receptor Binding Endoplasmic Reticulum Lumen Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Extracellular Matrix Heparin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Golgi Lumen Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Processing Regulation Of Protein Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Maturation Cell Surface Platelet Alpha Granule Lumen Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Nerve Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Amyloid-beta Binding Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Perinuclear Region Of Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Transport Positive Regulation Of MAPK Cascade