C4BPA and APCS

Number of citations of the paper that reports this interaction (PMID 7592941)
12

Data Source:
HPRD (in vitro)

		C4BPA	APCS
Gene Name		complement component 4 binding protein, alpha	amyloid P component, serum
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Other Organism Cell Blood Microparticle	Extracellular Region Extracellular Space Nucleus Extracellular Matrix Protein Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Poly(A) RNA Binding	Complement Component C1q Binding Calcium Ion Binding Carbohydrate Binding Virion Binding Unfolded Protein Binding
	Biological Process	Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Opsonization	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System	Amyloids
Drugs			Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE
Diseases
GWAS		C4b binding protein levels ( 20212171)	C-reactive protein ( 22939635)
Protein-Protein Interactions		9 interactors: APCS BMPR2 FXYD6 GIT2 GTF2I LBP LRP1 PROS1 SMARCD1	17 interactors: C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG
Entrez ID		722	325
HPRD ID		00403	00101
Ensembl ID		ENSG00000123838	ENSG00000132703
Uniprot IDs		P04003 Q5VVQ8	P02743
PDB IDs		2A55 4B0F	1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU
Enriched GO Terms of Interacting Partners?		Regulation Of Locomotion Acute-phase Response Regulation Of Inflammatory Response Artery Development Negative Regulation Of Wound Healing Regulation Of Acute Inflammatory Response Acute Inflammatory Response Beta-amyloid Clearance Regulation Of Metabolic Process Positive Regulation Of Chemotaxis Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Regulation Of Lung Blood Pressure Lipopolysaccharide Transport Transition Between Slow And Fast Fiber Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Behavior Regulation Of Wound Healing Negative Regulation Of Vasoconstriction Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Cell Migration Regulation Of Chemotaxis Regulation Of Cell Motility Regulation Of Cellular Component Movement Regulation Of Behavior Negative Regulation Of Monocyte Differentiation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Respiratory Burst Leukocyte Migration Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Skeletal Muscle Adaptation Lymphatic Endothelial Cell Differentiation Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Growth Negative Regulation Of Locomotion Phagocytosis Chromatin-mediated Maintenance Of Transcription Opsonization Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Regulation Of Phospholipase A2 Activity Positive Regulation Of Macrophage Activation Lymphangiogenesis Response To Stress Positive Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Glycoprotein Metabolic Process	Immune System Process Immune Response Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Vesicle-mediated Transport Positive Regulation Of Immune Response Retinal Blood Vessel Morphogenesis Response To Stimulus Defense Response Phagocytosis Retina Vasculature Morphogenesis In Camera-type Eye Endocytosis Complement Activation, Classical Pathway Transport Cell Morphogenesis Involved In Differentiation Humoral Immune Response Mediated By Circulating Immunoglobulin Retina Vasculature Development In Camera-type Eye Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Innate Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Blood Vessel Morphogenesis Protein Activation Cascade Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Platelet Activation Acute-phase Response Morphogenesis Of An Epithelium Blood Vessel Development Vasculature Development Generation Of Neurons Humoral Immune Response Morphogenesis Of A Branching Epithelium Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Neurogenesis Morphogenesis Of A Branching Structure Wound Healing Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Pharyngeal Arch Artery Morphogenesis Glycerol-3-phosphate Biosynthetic Process Lateral Inhibition Labyrinthine Layer Development Leukocyte Mediated Immunity Adaptive Immune Response Fc Receptor Signaling Pathway
Tagcloud ?			aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity
Tagcloud (Difference) ?			aggregates cd68 dendritic dysmaturation dysmorphic enlarged fdc fdcs follicle follicles idc idcs imply interdigitating intima ki67 kim lining lymphocyte lymphocytes pathogenetic phenomena proliferating regarded rheumatoid semiquantitative slcs synovial vicinity
Tagcloud (Intersection) ?