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NR2C2 and IKBKB
Number of citations of the paper that reports this interaction (PMID
12547194
)
82
Data Source:
HPRD
(in vivo, in vitro)
NR2C2
IKBKB
Gene Name
nuclear receptor subfamily 2, group C, member 2
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Membrane Raft
Molecular Function
Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Transcription Coactivator Activity
Receptor Activity
Protein Binding
Zinc Ion Binding
Sequence-specific DNA Binding
Protein Heterodimerization Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Biological Process
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Spermatogenesis
Nervous System Development
Gene Expression
Cerebellum Development
Cell Differentiation
Positive Regulation Of Embryonic Development
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Behavior
Meiotic Cell Cycle
B Cell Homeostasis
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Response To Virus
Positive Regulation Of Sodium Ion Transport
Positive Regulation Of Type I Interferon Production
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Serine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of Cation Channel Activity
Pathways
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Signaling by the B Cell Receptor (BCR)
NF-kB is activated and signals survival
RIP-mediated NFkB activation via ZBP1
IRAK1 recruits IKK complex
Downstream signaling events of B Cell Receptor (BCR)
Toll Like Receptor TLR1:TLR2 Cascade
FCERI mediated NF-kB activation
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
MyD88 dependent cascade initiated on endosome
Toll Like Receptor 9 (TLR9) Cascade
IRAK1 recruits IKK complex
TRIF-mediated TLR3/TLR4 signaling
Toll Like Receptor 2 (TLR2) Cascade
TCR signaling
Signaling by Interleukins
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Fc epsilon receptor (FCERI) signaling
Interleukin-1 signaling
Adaptive Immune System
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Downstream TCR signaling
p75NTR recruits signalling complexes
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
ZBP1(DAI) mediated induction of type I IFNs
p75NTR signals via NF-kB
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Innate Immune System
Signalling by NGF
IKK complex recruitment mediated by RIP1
Cytosolic sensors of pathogen-associated DNA
p75 NTR receptor-mediated signalling
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll-Like Receptors Cascades
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll Like Receptor 10 (TLR10) Cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Activation of NF-kappaB in B cells
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Mesalazine
Sulfasalazine
Auranofin
Arsenic trioxide
Diseases
GWAS
Alcohol and nictotine co-dependence (
22488850
)
Protein-Protein Interactions
21 interactors:
AR
CD2AP
CDC37
CHUK
ESR1
FKBP5
HDAC4
HNF4A
HSP90AA1
HSP90AB1
IKBKB
ITSN2
JAZF1
KDM1A
NR2C1
NR2C2AP
PEBP1
RXRB
TAB1
TAB2
TRAF2
78 interactors:
ACVR1
AKT1
AURKA
BCL10
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
CSF2RA
CSF2RB
CTNNB1
CUEDC2
EIF2AK2
EIF2AK3
FAF1
FANCA
FOXO3
HSP90AA1
HSP90AB1
HTT
IKBKAP
IKBKG
IRS1
JUN
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
RIPK1
ROCK1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
UBB
YWHAB
Entrez ID
7182
3551
HPRD ID
03253
04462
Ensembl ID
ENSG00000104365
Uniprot IDs
F2YGU2
P49116
Q6PHZ7
O14920
PDB IDs
3P0U
3BRT
3BRV
4E3C
4KIK
Enriched GO Terms of Interacting Partners
?
Intracellular Receptor Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Innate Immune Response
I-kappaB Kinase/NF-kappaB Signaling
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Transcription Initiation From RNA Polymerase II Promoter
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
DNA-templated Transcription, Initiation
Toll-like Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Hormone-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Fc Receptor Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Toll-like Receptor 5 Signaling Pathway
Activation Of Innate Immune Response
Toll-like Receptor 10 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Signaling
Toll-like Receptor 2 Signaling Pathway
Response To Organic Substance
Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Cellular Response To Steroid Hormone Stimulus
Regulation Of Immune Response
Regulation Of Metabolic Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Innate Immune Response
Positive Regulation Of Immune System Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Immune Response
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Innate Immune Response
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Innate Immune Response
Immune Response-regulating Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Immune System Process
Immune Response
Regulation Of Immune Response
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Defense Response
Regulation Of Phosphorylation
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Protein Phosphorylation
Positive Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Phosphorus Metabolic Process
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Cell Death
Innate Immune Response-activating Signal Transduction
Toll-like Receptor Signaling Pathway
Death
Positive Regulation Of Intracellular Signal Transduction
Apoptotic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Activation Of Innate Immune Response
Regulation Of Innate Immune Response
Programmed Cell Death
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Apoptotic Process
Immune System Process
Response To Stress
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Signaling
Response To Organic Substance
Positive Regulation Of Immune System Process
MyD88-independent Toll-like Receptor Signaling Pathway
Cell Communication
Cellular Response To Organic Substance
Regulation Of Cell Death
Positive Regulation Of Innate Immune Response
Negative Regulation Of Programmed Cell Death
Intracellular Signal Transduction
Cellular Response To Stimulus
Positive Regulation Of Phosphorylation
Tagcloud
?
abi
analyse
ctla4
episodes
genotyped
il4ra
il8
map3k1
mbl2
nfkbia
nfkbib
polymorphisms
prism
recurrent
rhinovirus
rs1800450ct
rs1801275gg
rs2146323aa
rs2233419ag
rs3087243ag
rs3136641tt
rs3747811at
rs3775291tc
rs4073at
rs702689aa
rs833058ct
tlr3
vegfa
wheezing
Tagcloud (Difference)
?
abi
analyse
ctla4
episodes
genotyped
il4ra
il8
map3k1
mbl2
nfkbia
nfkbib
polymorphisms
prism
recurrent
rhinovirus
rs1800450ct
rs1801275gg
rs2146323aa
rs2233419ag
rs3087243ag
rs3136641tt
rs3747811at
rs3775291tc
rs4073at
rs702689aa
rs833058ct
tlr3
vegfa
wheezing
Tagcloud (Intersection)
?