NR2C2 and HSP90AB1

Number of citations: 0 (PubMedID 14743216)
Data Source: HPRD (in vitro)

		NR2C2	HSP90AB1
Name		nuclear receptor subfamily 2 group C member 2	heat shock protein 90 alpha family class B member 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane COP9 Signalosome Cell Surface Membrane Protein-containing Complex Aryl Hydrocarbon Receptor Complex Secretory Granule Lumen Melanosome Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Protein Folding Chaperone Complex Dynein Axonemal Particle Ficolin-1-rich Granule Lumen HSP90-CDC37 Chaperone Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding ATP-dependent Protein Binding Protein Folding Chaperone Cadherin Binding Protein Dimerization Activity Tau Protein Binding Unfolded Protein Binding DNA Polymerase Binding Protein Phosphatase Activator Activity Disordered Domain Specific Binding ATP-dependent Protein Folding Chaperone Receptor Ligand Inhibitor Activity Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Spermatogenesis Nervous System Development Cell Differentiation Intracellular Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade	Placenta Development Protein Folding Response To Unfolded Protein Telomere Maintenance Via Telomerase Virion Attachment To Host Cell Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Protein Stabilization Chaperone-mediated Protein Complex Assembly Regulation Of Cell Cycle Cellular Response To Interleukin-4 Supramolecular Fiber Organization Negative Regulation Of Proteasomal Protein Catabolic Process Telomerase Holoenzyme Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Nuclear Receptor transcription pathway	DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of actin dynamics for phagocytic cup formation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase HSF1-dependent transactivation Sema3A PAK dependent Axon repulsion Uptake and function of diphtheria toxin Neutrophil degranulation The NLRP3 inflammasome The role of GTSE1 in G2/M progression after G2 checkpoint Aryl hydrocarbon receptor signalling ESR-mediated signaling RHOBTB2 GTPase cycle Estrogen-dependent gene expression Chaperone Mediated Autophagy Purinergic signaling in leishmaniasis infection Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Assembly and release of respiratory syncytial virus (RSV) virions Respiratory syncytial virus genome replication
Drugs		None	Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Radicicol Tanespimycin SNX-5422 CCT-018159 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Polaprezinc
GWAS		Alcohol and nicotine co-dependence ( 22488850 ) Femur bone mineral density x serum urate levels interaction ( 34046847 )	Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		23 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RXRB TAB1 TAB2 TRAF2 TRIM55	68 interacting genes: ACD AKT1 ANXA1 ARHGAP1 BTG3 CCT2 CDC37L1 CDK4 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 EGFR ENO1 ERBB2 ESR1 ESRRB FCHSD2 GSK3A GSK3B HSPB1 IKBKB IKBKE IKBKG ITGB1BP2 KEAP1 MAP3K14 MAP3K3 MAPK6 MKNK1 MYCBP2 NR2C2 NR3C1 NR4A1 OGT PGR POT1 PPID PTP4A2 RAF1 RHOBTB2 SERPINB5 SGTA SHKBP1 SIRPA SLC34A1 STARD13 STAT1 STAT3 SUMO2 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 UBE2D3 UBE3A UNC45A USP50 WASL WEE2-AS1 XIAP YWHAB
Entrez ID		7182	3326
HPRD ID		03253	06763
Ensembl ID		ENSG00000177463	ENSG00000096384
Uniprot IDs		F2YGU2 P49116	B4DGL0 P08238 Q6PK50
PDB IDs		3P0U 7XV6 7XV8 7XV9 7XVA	1QZ2 1UYM 2L6J 3FWV 3NMQ 3PRY 3UQ3 5FWK 5FWL 5FWM 5FWP 5UC4 5UCH 5UCI 5UCJ 6N8W 6N8Y 7ULJ 7Z37 7Z38 7ZR0 7ZR5 7ZR6 7ZUB 8EOA 8EOB 8GAE 8GFT 8QMO
GO Terms Enriched among Interactors		Regulation Of Signal Transduction Non-canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Intracellular Signal Transduction Nuclear Receptor Activity Regulation Of Signaling Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Nuclear Steroid Receptor Activity Intracellular Signaling Cassette Nitric-oxide Synthase Regulator Activity CD40 Receptor Complex Positive Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Modification Process HSP90-CDC37 Chaperone Complex Regulation Of Nitric Oxide Metabolic Process Protein Kinase Binding Scaffold Protein Binding Positive Regulation Of Signal Transduction Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway IkappaB Kinase Activity Rho GDP-dissociation Inhibitor Binding Protein-containing Complex Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor-mediated Signaling Pathway Protein Folding Chaperone Complex Cytosol Enzyme Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Innate Immune Response Telomerase Holoenzyme Complex Assembly Regulation Of Immune Response Histone Deacetylase Binding Nucleoplasm Response To External Biotic Stimulus IkappaB Kinase Complex Hormone-mediated Signaling Pathway Dendritic Growth Cone TPR Domain Binding	Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase Activity Intracellular Signaling Cassette Cytosol Positive Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Intracellular Signal Transduction Identical Protein Binding Kinase Activity Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Shelterin Complex Protein Serine Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Proteolysis Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process IkappaB Kinase Activity Nucleus Estrogen Response Element Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling