NR2C2 and NR2C1

Number of citations: 51 (PubMedID 30463901)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro, two hybrid, in vivo)

		NR2C2	NR2C1
Name		nuclear receptor subfamily 2 group C member 2	nuclear receptor subfamily 2 group C member 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm PML Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Signaling Receptor Activity Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Spermatogenesis Nervous System Development Cell Differentiation Intracellular Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways		Nuclear Receptor transcription pathway	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
GWAS		Alcohol and nicotine co-dependence ( 22488850 ) Femur bone mineral density x serum urate levels interaction ( 34046847 )	Body fat mass ( 28552196 ) Chromosomal aberration frequency (chromosome type) ( 31586183 ) Coronary artery disease ( 32469254 ) Intracranial aneurysm ( 33199917 ) Trunk fat mass ( 28552196 )
Novel Interactors		1 novel interactors: RPL36	1 novel interactors: SYNE2
Interacting Genes		23 interacting genes: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RAC1 RXRB TAB1 TAB2 TRAF2 TRIM55	8 interacting genes: AR ESR1 HDAC3 HDAC4 NR2C2 NRIP1 NUDT3 RARA
Entrez ID		7182	7181
HPRD ID		03253	03318
Ensembl ID		ENSG00000177463	ENSG00000120798
Uniprot IDs		F2YGU2 P49116	H9NIM2 H9NIM3 P13056
PDB IDs		3P0U 7XV6 7XV8 7XV9 7XVA	Not available
GO Terms Enriched among Interactors		Regulation Of Signal Transduction Non-canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Intracellular Signal Transduction Nuclear Receptor Activity Regulation Of Signaling Canonical NF-kappaB Signal Transduction Intracellular Receptor Signaling Pathway Nuclear Steroid Receptor Activity Intracellular Signaling Cassette Nitric-oxide Synthase Regulator Activity CD40 Receptor Complex Positive Regulation Of Intracellular Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Modification Process HSP90-CDC37 Chaperone Complex Regulation Of Nitric Oxide Metabolic Process Protein Kinase Binding Scaffold Protein Binding Positive Regulation Of Signal Transduction Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway IkappaB Kinase Activity Rho GDP-dissociation Inhibitor Binding Protein-containing Complex Positive Regulation Of Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor-mediated Signaling Pathway Protein Folding Chaperone Complex Cytosol Enzyme Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nitric Oxide Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Metabolic Process Cytoplasm Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Innate Immune Response Telomerase Holoenzyme Complex Assembly Regulation Of Immune Response Histone Deacetylase Binding Nucleoplasm Response To External Biotic Stimulus IkappaB Kinase Complex Hormone-mediated Signaling Pathway Dendritic Growth Cone TPR Domain Binding	Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Histone Deacetylase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Response To Estrogen Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Prostate Gland Growth Histone Deacetylase Activity, Hydrolytic Mechanism Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Response To Hormone Stimulus Protein Deacetylation Protein Lysine Deacetylase Activity Male Gonad Development Response To Lipid Response To Estradiol Enzyme Binding Mammary Gland Alveolus Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Myotube Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gonad Development Histone Deacetylase Activity Hormone-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Nucleoplasm Nuclear Steroid Receptor Activity Cellular Response To Lipid Prostate Gland Epithelium Morphogenesis