NR2C2 and NR2C1

Number of citations of the paper that reports this interaction (PMID 12093744)
35

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		NR2C2	NR2C1
Gene Name		nuclear receptor subfamily 2, group C, member 2	nuclear receptor subfamily 2, group C, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleoplasm PML Body
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Receptor Activity Protein Binding Zinc Ion Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Spermatogenesis Nervous System Development Gene Expression Cerebellum Development Cell Differentiation Positive Regulation Of Embryonic Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Behavior Meiotic Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway	Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Alcohol and nictotine co-dependence ( 22488850)
Protein-Protein Interactions		21 interactors: AR CD2AP CDC37 CHUK ESR1 FKBP5 HDAC4 HNF4A HSP90AA1 HSP90AB1 IKBKB ITSN2 JAZF1 KDM1A NR2C1 NR2C2AP PEBP1 RXRB TAB1 TAB2 TRAF2	8 interactors: AR ESR1 HDAC3 HDAC4 NR2C2 NRIP1 NUDT3 UBC
Entrez ID		7182	7181
HPRD ID		03253	03318
Ensembl ID			ENSG00000120798
Uniprot IDs		F2YGU2 P49116 Q6PHZ7	H9NIM2 H9NIM3 P13056
PDB IDs		3P0U
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Toll-like Receptor Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 5 Signaling Pathway Activation Of Innate Immune Response Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Signaling Toll-like Receptor 2 Signaling Pathway Response To Organic Substance Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Regulation Of Immune Response Regulation Of Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Immune Response Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway	Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA-templated Transcription, Initiation Transcription, DNA-templated RNA Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Rhythmic Process Nucleobase-containing Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Steroid Hormone Mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Hormone-mediated Signaling Pathway Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Signaling Cell Communication Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Circadian Rhythm Negative Regulation Of Gene Expression Histone H4 Deacetylation Negative Regulation Of Biosynthetic Process Response To Organic Substance Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Histone H3 Deacetylation Androgen Receptor Signaling Pathway Histone H3-K9 Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Sex Differentiation Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance
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