TRIP6 and THRB

Number of citations of the paper that reports this interaction (PMID 7776974)
105

Data Source:
HPRD (in vivo, two hybrid)

		TRIP6	THRB
Gene Name		thyroid hormone receptor interactor 6	thyroid hormone receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex	Nuclear Chromatin Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Thyroid Hormone Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Organ Morphogenesis Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Type I Pneumocyte Differentiation
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			Liothyronine Levothyroxine Dextrothyroxine Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid GC-24 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
Diseases
GWAS		Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)	Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1	58 interactors: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF EIF3I ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 ZNHIT3
Entrez ID		7205	7068
HPRD ID		04242	07521
Ensembl ID		ENSG00000087077	ENSG00000151090
Uniprot IDs		F2ZC06 Q15654	F1D8N7 P10828
PDB IDs		1X61 2DLO	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC
Enriched GO Terms of Interacting Partners?		Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Response To Steroid Hormone
Tagcloud ?		adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression	approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed
Tagcloud (Difference) ?		adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression	approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed
Tagcloud (Intersection) ?