TRIP6 and LPAR2

Number of citations of the paper that reports this interaction (PMID 14688263)
28

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		TRIP6	LPAR2
Gene Name		thyroid hormone receptor interactor 6	lysophosphatidic acid receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Interleukin-1 Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle
	Molecular Function	Interleukin-1 Receptor Binding Protein Binding Zinc Ion Binding Kinase Binding Poly(A) RNA Binding Thyroid Hormone Receptor Binding	G-protein Coupled Receptor Activity Protein Binding Lipid Binding PDZ Domain Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Cell Migration Focal Adhesion Assembly	Activation Of MAPK Activity G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Rho Protein Signal Transduction
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020)	Sphingolipid levels ( 22359512)
Protein-Protein Interactions		105 interactors: ABI2 ADAMTSL4 AQP1 ARNT2 ATN1 ATP5O ATXN1 BCAR1 BYSL CATSPER1 CBLC CCL5 CEP57L1 CNTF CREB5 CTAG2 DHX37 DMRT3 DTX2 EXOC3-AS1 FAM124B FAM154A FAM46C FASLG FHL3 FRS3 GDPD5 GFI1B GNAI2 GSE1 HLA-DPB1 HOXA1 HOXA9 HOXB9 HYKK ILF3 INCA1 KIAA1683 KIF1A KIR2DL4 KLK15 KRTAP26-1 LMO2 LOC149950 LPAR2 MAPKBP1 MEMO1 METTL17 MSRB3 MVP NCK2 NEDD9 NEU4 NUP210 ODF1 OIP5 OTUB2 PDGFRB PDLIM4 PIN1 POM121 POM121L4P PPP1R16A PRKAA1 PRKAA2 PTK2 PTPN13 PXN RAD23A RERE RFX3 RHOA RHOQ RNF213 RNF214 SCRIB SIK3 SLC15A3 SLC25A6 SMAD1 SON SRC STAC STK16 SVIL SYNGAP1 TAB1 TCAF1 TEKT4 THRB TLR2 TMSB4X TPM3 TPM4 TRAF3IP2 TRAPPC2L TRIM29 TTLL10 TXN2 TXNDC5 VCL WT1-AS XRCC6BP1 YPEL3 ZBP1	6 interactors: ARHGEF11 ARHGEF12 ATXN1 SLC9A3R1 SLC9A3R2 TRIP6
Entrez ID		7205	9170
HPRD ID		04242	05487
Ensembl ID		ENSG00000087077	ENSG00000064547
Uniprot IDs		F2ZC06 Q15654	Q9HBW0
PDB IDs		1X61 2DLO
Enriched GO Terms of Interacting Partners?		Signal Complex Assembly Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Organic Substance Regulation Of Signaling Actin Filament-based Process Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Cytoskeleton Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Signal Transduction ERBB Signaling Pathway Cell Communication Cellular Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Phosphorylation Multicellular Organismal Development Regulation Of Apoptotic Process Response To Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Transforming Growth Factor Beta Regulation Of Protein Phosphorylation Cellular Response To Stimulus Platelet Activation Response To Hormone Response To Stress Cellular Response To Growth Factor Stimulus Response To Wounding Regulation Of Protein Metabolic Process Regulation Of Cell Death Actin Cytoskeleton Organization Wound Healing Signaling Transforming Growth Factor Beta Receptor Signaling Pathway Organ Development Regulation Of Cell Motility Cell Motility Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process	Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Renal Phosphate Ion Absorption Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Renal Sodium Ion Transport Release Of Cytoplasmic Sequestered NF-kappaB Neurotrophin Signaling Pathway Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Rho GTPase Activity Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Rho GTPase Activity G-protein Coupled Receptor Signaling Pathway Cell Projection Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Bile Acid Secretion Regulation Of Rho Protein Signal Transduction Oligopeptide Transport Apoptotic Signaling Pathway Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phosphate Ion Homeostasis Signaling Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Assembly Axon Guidance Negative Regulation Of Phosphorylation Cell Communication Regulation Of Apoptotic Process Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Intracellular Signal Transduction
Tagcloud ?		adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression	aggressive anchorage cascade colony concurrent cox cxcl1 database differentially dramatically dual engraftment ezh2 il interleukin multivariable offer predicted proved rationale specimens stanched strategy therapies times tnbc tnbcs triple
Tagcloud (Difference) ?		adaptors ap competition dimerization discrete domains enables enhances example exerts focal glucocorticoid gr interacts intriguing isoform lim med1 mediating mediator negatively orchestrating promoters recruitment tethering thought thrap3 transrepression	aggressive anchorage cascade colony concurrent cox cxcl1 database differentially dramatically dual engraftment ezh2 il interleukin multivariable offer predicted proved rationale specimens stanched strategy therapies times tnbc tnbcs triple
Tagcloud (Intersection) ?