HIPK3 and FLNC

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		HIPK3	FLNC
Gene Name		homeodomain interacting protein kinase 3	filamin C, gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding	Protein Binding Cytoskeletal Protein Binding Ankyrin Binding Actin Filament Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Cell Junction Assembly Muscle Fiber Development
Pathways			Cell junction organization Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AR ARRB2 C1QA CREB1 DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	29 interactors: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 INPPL1 KCND2 KY MAP2K4 MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2
Entrez ID		10114	2318
HPRD ID		05111	00018
Ensembl ID		ENSG00000110422	ENSG00000128591
Uniprot IDs		Q9H422	Q14315 Q59H94
PDB IDs			1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Negative Regulation Of Gene Expression Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Motor Neuron Apoptotic Process Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Protein Oligomerization RNA Biosynthetic Process Response To Organic Substance Cellular Response To Organic Substance RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway Viral Process Regulation Of RNA Splicing Cellular Metabolic Process RNA Processing Cellular Response To Growth Factor Stimulus Androgen Receptor Signaling Pathway Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signaling Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Muscle Cell Development Blood Circulation Muscle Structure Development Heart Development Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Cardiovascular System Development Positive Regulation Of Systemic Arterial Blood Pressure Adrenergic Receptor Signaling Pathway Muscle Cell Differentiation Regulation Of Blood Pressure Negative Regulation Of The Force Of Heart Contraction Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Cardiac Muscle Tissue Development Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Organ Development Multicellular Organismal Development Developmental Process Regulation Of The Force Of Heart Contraction Vasoconstriction Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Muscle Organ Development Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Peptidyl-threonine Phosphorylation Striated Muscle Tissue Development Striated Muscle Cell Development System Development Muscle Tissue Development Regulation Of Heart Contraction Anatomical Structure Development Actin Cytoskeleton Organization Regulation Of The Force Of Heart Contraction By Chemical Signal Heart Contraction Actin Filament-based Process Myofibril Assembly Cell Development Regulation Of Blood Vessel Size Cellular Response To Carbohydrate Stimulus Regulation Of Tube Size Striated Muscle Cell Differentiation Adult Heart Development Muscle System Process Signaling Organ Growth Actomyosin Structure Organization Cell Communication Positive Regulation Of Heart Rate Peptidyl-serine Phosphorylation
Tagcloud ?			adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?			adh6 aflatoxin areca arecoline bard1 betel brms1 ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?