HIPK3 and SRSF5

Number of citations of the paper that reports this interaction (PMID 16000324)
18

Data Source:
BioGRID (unspecified method)

		HIPK3	SRSF5
Gene Name		homeodomain interacting protein kinase 3	serine/arginine-rich splicing factor 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body	Nucleus Nucleoplasm Nucleolus Cytoplasm Nuclear Speck
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity ATP Binding	Nucleotide Binding Protein Binding Poly(A) RNA Binding RS Domain Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Splice Site Selection MRNA Processing MRNA Export From Nucleus RNA Splicing Response To Wounding Gene Expression MRNA 3'-end Processing Regulation Of Cell Cycle
Pathways			mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		36 interactors: AR ARRB2 C1QA CREB1 DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	16 interactors: CALM1 CD101 DYRK1A HIPK3 MAPK14 MAPK6 OLFM2 PPARGC1A RPS6KA1 SMURF1 SNRPF SREK1 SRPK1 SRPK2 SRSF1 TNK2
Entrez ID		10114	6430
HPRD ID		05111	02948
Ensembl ID		ENSG00000110422	ENSG00000100650
Uniprot IDs		Q9H422	Q13243 Q86U32
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Component Assembly Negative Regulation Of Gene Expression Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Signal Transduction Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Motor Neuron Apoptotic Process Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Protein Oligomerization RNA Biosynthetic Process Response To Organic Substance Cellular Response To Organic Substance RNA Splicing Regulation Of Extrinsic Apoptotic Signaling Pathway Viral Process Regulation Of RNA Splicing Cellular Metabolic Process RNA Processing Cellular Response To Growth Factor Stimulus Androgen Receptor Signaling Pathway Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Signaling Necroptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Processing Regulation Of RNA Splicing Protein Phosphorylation Phosphorylation MRNA Metabolic Process RNA Processing Innate Immune Response Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Peptidyl-serine Phosphorylation Cellular Protein Modification Process Positive Regulation Of Viral Genome Replication Intracellular Signal Transduction Glucose Metabolic Process Immune Response Defense Response Posttranscriptional Regulation Of Gene Expression Ribonucleoprotein Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Cellular Metabolic Process Termination Of RNA Polymerase II Transcription Hexose Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Peptidyl-threonine Phosphorylation MAPK Cascade Negative Regulation Of Viral Genome Replication MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Cellular Response To Growth Factor Stimulus Signal Transduction Monosaccharide Metabolic Process Regulation Of MRNA Stability Response To Growth Factor Toll-like Receptor 5 Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Stability Toll-like Receptor 10 Signaling Pathway Cellular Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Nuclear Speck Organization P38MAPK Cascade
Tagcloud ?			a014418 antiapoptotic anxa7 ar bcl2 bmi1 deregulation downregulating downregulation escape factual glioblastoma glycogen gsk3 gsk3alpha gsk3beta hnrnp manzamine mcl1 posttreatment ptpb1 reflected splicing srsf1 tyr u373 u87 va xl
Tagcloud (Difference) ?			a014418 antiapoptotic anxa7 ar bcl2 bmi1 deregulation downregulating downregulation escape factual glioblastoma glycogen gsk3 gsk3alpha gsk3beta hnrnp manzamine mcl1 posttreatment ptpb1 reflected splicing srsf1 tyr u373 u87 va xl
Tagcloud (Intersection) ?