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HIPK3 and HEYL
Number of citations of the paper that reports this interaction (PMID
15231748
)
65
Data Source:
HPRD
(two hybrid)
HIPK3
HEYL
Gene Name
homeodomain interacting protein kinase 3
hes-related family bHLH transcription factor with YRPW motif-like
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
PML Body
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
ATP Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding Transcription Factor Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Transcription Corepressor Activity
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Microsatellite Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
AF-1 Domain Binding
Biological Process
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Apoptotic Process
MRNA Transcription
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Negative Regulation Of Apoptotic Process
Negative Regulation Of JUN Kinase Activity
Outflow Tract Morphogenesis
Atrioventricular Valve Morphogenesis
Pulmonary Valve Morphogenesis
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Endocardial Cushion Morphogenesis
Cardiac Ventricle Morphogenesis
Transcription From RNA Polymerase II Promoter
Notch Signaling Pathway
Mesenchymal Cell Development
Glomerulus Development
Skeletal Muscle Cell Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Cardiac Epithelial To Mesenchymal Transition
Ventricular Septum Morphogenesis
Negative Regulation Of Androgen Receptor Signaling Pathway
Cellular Response To BMP Stimulus
Proximal Tubule Development
Negative Regulation Of Androgen Receptor Activity
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
NOTCH1 Intracellular Domain Regulates Transcription
Signaling by NOTCH1
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Red blood cell traits (
23222517
)
Protein-Protein Interactions
36 interactors:
AR
ARRB2
C1QA
CREB1
DAXX
FADD
FAS
FLNC
GLUL
GORASP1
GRB2
HEYL
HNRNPA1
HNRNPA2B1
HNRNPH1
LIMD1
LIMK2
LIMS2
MBD1
MTMR4
NR2F2
RGS3
SIAH1
SIAH2
SKIL
SNIP1
SRSF1
SRSF5
SUMO1
TGFB1I1
TOX4
TP73
TRA2B
UBE2I
ZNF107
ZYX
18 interactors:
APP
ATF7IP
ATXN1
HAND1
HAND2
HIPK3
HTT
LAPTM5
MDFI
PPP1CA
RBPMS
RPGRIP1
SKIL
SMAD3
SMAD7
SMAD9
SP8
ZNF512B
Entrez ID
10114
26508
HPRD ID
05111
16419
Ensembl ID
ENSG00000110422
ENSG00000163909
Uniprot IDs
Q9H422
F5H3V9
Q9NQ87
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Signaling
Regulation Of Signal Transduction
Regulation Of RNA Metabolic Process
RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Gene Expression
Regulation Of Metabolic Process
Regulation Of Gene Expression
Regulation Of Cellular Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Component Assembly
Negative Regulation Of Gene Expression
Negative Regulation Of Signal Transduction
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Apoptotic Signaling Pathway
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Signaling
Negative Regulation Of Cellular Metabolic Process
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Positive Regulation Of Signal Transduction
Regulation Of Transcription, DNA-templated
Heterocycle Metabolic Process
Motor Neuron Apoptotic Process
Transcription, DNA-templated
Cellular Aromatic Compound Metabolic Process
Protein Oligomerization
RNA Biosynthetic Process
Response To Organic Substance
Cellular Response To Organic Substance
RNA Splicing
Regulation Of Extrinsic Apoptotic Signaling Pathway
Viral Process
Regulation Of RNA Splicing
Cellular Metabolic Process
RNA Processing
Cellular Response To Growth Factor Stimulus
Androgen Receptor Signaling Pathway
Response To Growth Factor
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Signaling
Necroptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Anatomical Structure Morphogenesis
RNA Metabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Organ Development
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Transforming Growth Factor Beta
Heterocycle Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Tube Development
Epithelium Development
Negative Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Pattern Specification Process
Negative Regulation Of Signaling
Regulation Of Binding
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Macromolecule Biosynthetic Process
Tissue Development
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Signaling
Positive Regulation Of Transcription, DNA-templated
Multicellular Organismal Development
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Cardiac Right Ventricle Formation
Anatomical Structure Development
Positive Regulation Of Cellular Metabolic Process
Organ Morphogenesis
Negative Regulation Of DNA Binding
Embryonic Morphogenesis
System Development
Tagcloud
?
bad
bromide
cancerous
dimethylthiazol
diphenyltetrazolium
egfp
eighty
expressional
hairy
hcc
hep
hypermethylation
inactivated
lentiviral
overexpress
p19
pheyl
preceded
qpcr
repressor
resected
ribose
shheyl
silence
sk
split
surgically
yrpw
Tagcloud (Difference)
?
bad
bromide
cancerous
dimethylthiazol
diphenyltetrazolium
egfp
eighty
expressional
hairy
hcc
hep
hypermethylation
inactivated
lentiviral
overexpress
p19
pheyl
preceded
qpcr
repressor
resected
ribose
shheyl
silence
sk
split
surgically
yrpw
Tagcloud (Intersection)
?