HIPK3 and MTMR4

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HIPK3	MTMR4
Description		homeodomain interacting protein kinase 3	myotubularin related protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body	Extracellular Space Cytoplasm Endosome Cytosol Endosome Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Early Phagosome Membrane Recycling Endosome Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Molecular Adaptor Activity R-SMAD Binding
	Biological Process	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Phosphatidylinositol Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Phosphatidylinositol Dephosphorylation Midbody Abscission Phagosome Maturation Negative Regulation Of Endocytic Recycling
Pathways			Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Downregulation of TGF-beta receptor signaling
Drugs		Fostamatinib
Diseases
GWAS		Anger ( 24489884) Obese vs. thin ( 30677029) Sleep (1/3-day periodicity) ( 33075057) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Cognitive function ( 25644384) Refractive error ( 32231278) Vitamin D levels ( 25208829)
Interacting Genes		37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	2 interacting genes: HIPK3 NEDD4
Entrez ID		10114	9110
HPRD ID		05111	11945
Ensembl ID		ENSG00000110422	ENSG00000108389
Uniprot IDs		A8KAE4 Q9H422	A0A804HJV7 Q9NYA4
PDB IDs		7O7I 7O7J
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Cytosol Nucleoplasm Regulation Of Gene Expression RNA Splicing Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein Kinase B Binding Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Signal Transduction Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome MRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cellular Response To Sodium Arsenite Double-stranded Methylated DNA Binding Small Protein Activating Enzyme Binding Regulation Of RNA Splicing Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding	Sodium Channel Inhibitor Activity DNA-templated Transcription Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Formation Of Structure Involved In A Symbiotic Process Negative Regulation Of JUN Kinase Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Potassium Channel Inhibitor Activity Endocardial Cushion Development Negative Regulation Of Sodium Ion Transport Proline-rich Region Binding Receptor Catabolic Process RNA Polymerase Binding Negative Regulation Of Potassium Ion Transmembrane Transport Nucleobase-containing Compound Biosynthetic Process Peptidyl-threonine Phosphorylation Negative Regulation Of MAP Kinase Activity Apicolateral Plasma Membrane Viral Budding Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Protein Targeting To Lysosome Negative Regulation Of Potassium Ion Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of JNK Cascade Neuromuscular Junction Development Peptidyl-serine Phosphorylation Receptor Metabolic Process Protein Localization To Lysosome Protein Modification Process Negative Regulation Of Signal Transduction Receptor Internalization Regulation Of Dendrite Morphogenesis Establishment Of Protein Localization To Vacuole Negative Regulation Of Cation Transmembrane Transport Mesenchyme Development RNA Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cell Communication Outflow Tract Morphogenesis Steroid Hormone Receptor Signaling Pathway
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