HIPK3 and LIMD1

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		HIPK3	LIMD1
Description		homeodomain interacting protein kinase 3	LIM domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body	P-body Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion RISC Complex Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Response To Hypoxia Osteoblast Development Regulation Of DNA-templated Transcription Cytoskeleton Organization Regulation Of Cell Shape Phosphorylation Cell Migration Regulatory NcRNA-mediated Gene Silencing P-body Assembly MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Hippo Signaling Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Fostamatinib
Diseases
GWAS		Anger ( 24489884) Obese vs. thin ( 30677029) Sleep (1/3-day periodicity) ( 33075057) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418)
Interacting Genes		37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	6 interacting genes: APP BRCA2 HIPK3 RPP14 STAC TRAF6
Entrez ID		10114	8994
HPRD ID		05111	05177
Ensembl ID		ENSG00000110422	ENSG00000144791
Uniprot IDs		A8KAE4 Q9H422	Q9UGP4
PDB IDs		7O7I 7O7J
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Cytosol Nucleoplasm Regulation Of Gene Expression RNA Splicing Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein Kinase B Binding Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Signal Transduction Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome MRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cellular Response To Sodium Arsenite Double-stranded Methylated DNA Binding Small Protein Activating Enzyme Binding Regulation Of RNA Splicing Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding	Regulation Of JNK Cascade Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Response To Interleukin-1 Regulation Of Phosphorus Metabolic Process Growth Cone Lamellipodium Positive Regulation Of Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Positive Regulation Of Interleukin-6 Production Amylin Binding Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Myeloid Leukocyte Activation Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Mitotic Recombination-dependent Replication Fork Processing BRCA2-MAGE-D1 Complex Cytoplasmic Side Of Plasma Membrane Regulation Of MAP Kinase Activity MRNA Transcription Regulation Of Protein Serine/threonine Kinase Activity Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cell Maturation Regulation Of Interleukin-6 Production Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Regulation Of MAPK Cascade Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Protein Localization To Membrane Positive Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Protein Localization To Cell Periphery Endoribonuclease Complex Ribonuclease P Complex
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