HIPK3 and GLUL

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		HIPK3	GLUL
Description		homeodomain interacting protein kinase 3	glutamate-ammonia ligase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Body PML Body	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Cell Body Extracellular Exosome Glial Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleotide Binding Catalytic Activity Glutamine Synthetase Activity Protein Binding ATP Binding Transferase Activity Ligase Activity Protein-cysteine S-palmitoyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Apoptotic Process MRNA Transcription Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity	Angiogenesis L-glutamate Catabolic Process Glutamine Biosynthetic Process Cell Population Proliferation Cellular Response To Starvation Response To Glucose Regulation Of Endothelial Cell Migration Protein Palmitoylation Ribosome Biogenesis Positive Regulation Of Erythrocyte Differentiation Intracellular Ammonium Homeostasis Regulation Of Sprouting Angiogenesis Regulation Of Protein Localization To Nucleolus
Pathways			Astrocytic Glutamate-Glutamine Uptake And Metabolism Glutamate and glutamine metabolism
Drugs		Fostamatinib	L-Glutamine Glutamic acid
Diseases			Congenital systemic glutamine deficiency (CSGD); Glutamine synthetase deficiency
GWAS		Anger ( 24489884) Obese vs. thin ( 30677029) Sleep (1/3-day periodicity) ( 33075057) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Cardiovascular heart disease in diabetics ( 23982368) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) HDL cholesterol levels ( 32203549) Morning person ( 30696823) Peak height velocity ( 34047840)
Interacting Genes		37 interacting genes: AR ARRB2 C1QA CREB1 CREBBP DAXX FADD FAS FLNC GLUL GORASP1 GRB2 HEYL HNRNPA1 HNRNPA2B1 HNRNPH1 LIMD1 LIMK2 LIMS2 MBD1 MTMR4 NR2F2 RGS3 SIAH1 SIAH2 SKIL SNIP1 SRSF1 SRSF5 SUMO1 TGFB1I1 TOX4 TP73 TRA2B UBE2I ZNF107 ZYX	27 interacting genes: BTG3 CASP8AP2 CRBN CYP39A1 DSCAM DYNLL1 EP300 HIPK1 HIPK3 HSD17B10 HTR2A LCOR MT-ND5 NFKB1 NUDT18 PIAS1 PIAS2 PIAS3 PLEKHF2 PPARD RABEPK RBBP6 RSPH1 SKIL TAT UBE2I USP15
Entrez ID		10114	2752
HPRD ID		05111	00701
Ensembl ID		ENSG00000110422	ENSG00000135821
Uniprot IDs		A8KAE4 Q9H422	A8YXX4 P15104
PDB IDs		7O7I 7O7J	2OJW 2QC8 7EVT 8DNU
Enriched GO Terms of Interacting Partners?		Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Splicing, Via Transesterification Reactions Cytosol Nucleoplasm Regulation Of Gene Expression RNA Splicing Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein Kinase B Binding Cell Surface Receptor Signaling Pathway Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Signal Transduction Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Catalytic Step 2 Spliceosome MRNA Processing Positive Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Cellular Response To Sodium Arsenite Double-stranded Methylated DNA Binding Small Protein Activating Enzyme Binding Regulation Of RNA Splicing Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Identical Protein Binding	PML Body SUMO Transferase Activity SUMO Ligase Activity Transcription Coregulator Activity Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of RNA Metabolic Process Ribonucleoside Diphosphate Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Purine Ribonucleoside Diphosphate Catabolic Process Transcription Coactivator Binding Nucleoside Diphosphate Catabolic Process Protein Modification Process Apoptotic Signaling Pathway Positive Regulation Of Protein Sumoylation Purine Ribonucleotide Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ribonucleoside Diphosphate Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Post-translational Protein Modification Nucleoside Diphosphate Metabolic Process Transcription Corepressor Activity Positive Regulation Of Cell Differentiation Apoptotic Process Purine Nucleotide Catabolic Process Negative Regulation Of Biosynthetic Process Catabolic Process Negative Regulation Of Metabolic Process Programmed Cell Death Cell Death Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Bile Acid Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Protein Sumoylation Nucleotide Catabolic Process Monocarboxylic Acid Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Developmental Process Retina Layer Formation Extrinsic Apoptotic Signaling Pathway Organic Acid Metabolic Process Purine Ribonucleotide Metabolic Process Nucleobase-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy
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