BCAS2 and SNRNP200

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		BCAS2	SNRNP200
Description		BCAS2 pre-mRNA processing factor	small nuclear ribonucleoprotein U5 subunit 200
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GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nucleolus Centrosome Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Plasma Membrane Cilium Membrane Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Ovarian Follicle Development MRNA Processing RNA Splicing Protein Catabolic Process Oogenesis Oocyte Development Spindle Assembly	Cis Assembly Of Pre-catalytic Spliceosome Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) MRNA Splicing, Via Spliceosome Osteoblast Differentiation MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases			Retinitis pigmentosa (RP)
GWAS		Autism ( 24189344) Chronotype ( 30696823)
Interacting Genes		82 interacting genes: ACY1 AIMP2 ANKHD1 BLK CCDC120 CCDC17 CNOT4 CPSF7 DMRTB1 DUT ECM1 EIF4ENIF1 EMILIN3 ENKD1 EP300 ESR1 ESR2 FAM86C1P FHIT GOLGA2 HGS HNRNPLL HSF2BP IFI35 IKZF3 KRT20 KRT27 KRT31 KRT34 KRT35 KRT36 KRT37 KRT75 KRTAP19-6 KRTAP8-1 LARP4 LMO1 LMO2 LMO3 LMO4 MBNL1 MED29 MIIP MYOZ3 NIP7 OIP5 PAX5 PCBD2 PFDN5 PGR PLAGL2 PLEKHF2 POT1 PPARG PRRC2B QKI RBM22 RBPMS RPL5 SAXO4 SF1 SLAIN1 SMARCD1 SNRNP200 SNRPC SNW1 SPMIP5 SPMIP6 TCF4 TCHP TFIP11 TP53BP2 TRAF1 TRNAU1AP TXN2 TXNRD2 UBC USHBP1 WDR83 YPEL3 ZMAT5 ZWINT	33 interacting genes: APC BARD1 BCAS2 BRCA1 CEBPA CHMP1B CREBBP DHX38 DUX4 ECT2 ERG GNMT GRB2 HSPB1 LCOR LSM8 MEGF10 PIN1 PRPF3 PRPF31 PRPF6 PTEN RNF10 RNF113A SF3B3 SMNDC1 SUMO2 UBE2I USP19 USP7 VHL YWHAB YWHAG
Entrez ID		10286	23020
HPRD ID		05777	03391
Ensembl ID		ENSG00000116752	ENSG00000144028
Uniprot IDs		B2R7W3 O75934	O75643
PDB IDs		5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV 7A5P 7W59 7W5A 7W5B 8C6J 8CH6 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD	2Q0Z 3JCR 4F91 4F92 4F93 4KIT 5O9Z 5URJ 5URK 5URM 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6QDV 6QW6 6QX9 6S8O 6S8Q 6S9I 7A5P 7ABG 7ABI 7BDI 7BDJ 7BDK 7BDL 7DVQ 7OS1 7OS2 7PX3 7W5B 8BC8 8BC9 8BCA 8BCB 8BCC 8BCD 8BCE 8BCF 8BCG 8BCH 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0W 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP9 8QPA 8QPB 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8Y6O 9FMD
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Organization Intermediate Filament Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Binding Nucleic Acid Binding MRNA Metabolic Process MRNA Processing Structural Molecule Activity Spliceosomal Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Estrogen Response Element Binding RNA Binding RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding RNA Processing Catalytic Step 2 Spliceosome Nucleus Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nuclear Receptor Activity Nuclear Estrogen Receptor Activity TFIIB-class Transcription Factor Binding Nuclear Receptor-mediated Signaling Pathway Epithelial Cell Differentiation Nuclear Steroid Receptor Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Morphogenesis Of An Epithelium MRNA Binding DNA-binding Transcription Factor Binding Regulation Of RNA Splicing Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Protein-containing Complex Organization Steroid Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cell Differentiation Supramolecular Fiber Organization Hormone-mediated Signaling Pathway Tissue Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization	Nucleoplasm Spliceosomal Complex RNA Splicing, Via Transesterification Reactions U2-type Precatalytic Spliceosome Nucleus Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing MRNA Processing Post-translational Protein Modification Protein Stabilization Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Protein Modification Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Primary Metabolic Process Nuclear Speck MRNA Metabolic Process RNA Binding Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Protein Modification By Small Protein Conjugation Spliceosomal Tri-snRNP Complex Assembly Protein Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Protein Stability Regulation Of Cell Cycle Process Nucleic Acid Metabolic Process Regulation Of Metabolic Process Protein Kinase C Inhibitor Activity Cellular Response To Ionizing Radiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein K6-linked Ubiquitination Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Cellular Response To Radiation Regulation Of Cell Cycle BRCA1-B Complex Postsynaptic Cytosol U2-type Spliceosomal Complex RNA Processing Catalytic Step 2 Spliceosome
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