PPP2R2B and CHEK2

Number of citations of the paper that reports this interaction (PMID 16596250)
9

Data Source:
HPRD (in vitro, in vivo)

		PPP2R2B	CHEK2
Gene Name		protein phosphatase 2, regulatory subunit B, beta	checkpoint kinase 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Mitochondrion Mitochondrial Outer Membrane Cytoskeleton	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body
	Molecular Function	Protein Binding Protein Phosphatase Type 2A Regulator Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Apoptotic Process Signal Transduction Regulation Of Catalytic Activity	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence
Pathways
Drugs
Diseases
GWAS		Alcohol dependence ( 19581569) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885)	Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		5 interactors: CHEK2 KLHL15 RAC1 TOP1 TP53	47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL
Entrez ID		5521	11200
HPRD ID		05059	05084
Ensembl ID		ENSG00000156475	ENSG00000183765
Uniprot IDs		Q00005	O96017
PDB IDs			1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		Regulation Of DNA Replication Replicative Senescence Programmed Cell Death Cell Death Death Apoptotic Signaling Pathway Negative Regulation Of DNA Replication Response To Gamma Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Cell Aging Viral Process Response To Osmotic Stress Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Metabolic Process Mitotic DNA Integrity Checkpoint Signal Transduction Involved In Intra-S DNA Damage Checkpoint Response To Ionizing Radiation Double-strand Break Repair DNA Damage Checkpoint Negative Regulation Of Macromitophagy Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Interleukin-23 Production Oligodendrocyte Apoptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Mitotic Cell Cycle Checkpoint Positive Regulation Of Protein Complex Assembly Circadian Rhythm Engulfment Of Apoptotic Cell Negative Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway Apoptotic Process Protein Complex Assembly Mast Cell Chemotaxis DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Embryo Development Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging DNA Conformation Change Mitochondrial DNA Repair Organelle Organization Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment	Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		allele arg72pro associates curves died ethnically gender genotyped genotypes interested kaplan lifespan lived llis log longevity mdm4 meier rank respective rs1042522 rs1563828 rs2279744 rs319217 rs4245739 snp309 snp31826 snp34091 snps	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		allele arg72pro associates curves died ethnically gender genotyped genotypes interested kaplan lifespan lived llis log longevity mdm4 meier rank respective rs1042522 rs1563828 rs2279744 rs319217 rs4245739 snp309 snp31826 snp34091 snps	alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?