TPM1 and TMOD2

Number of citations of the paper that reports this interaction (PMID 8886980)
14

Data Source:
HPRD (in vitro)

		TPM1	TMOD2
Gene Name		tropomyosin 1 (alpha)	tropomodulin 2 (neuronal)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Sarcomere Filamentous Actin Bleb Ruffle Membrane	Striated Muscle Thin Filament Growth Cone
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Muscle	Actin Binding Tropomyosin Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Heart Rate By Epinephrine Movement Of Cell Or Subcellular Component Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Muscle Contraction Actin Filament Organization Neuron-neuron Synaptic Transmission Nervous System Development Learning Or Memory Myofibril Assembly Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Pointed-end Actin Filament Capping
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Mean platelet volume ( 19820697) Orofacial clefts ( 22863734) Platelet counts ( 22139419)
Protein-Protein Interactions		18 interactors: ACTB C1orf216 CAGE1 EGFR EPB41 GOLGA2 JUN KXD1 MAD1L1 PKD2 S100A2 SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4	3 interactors: APP TPM1 TPM3
Entrez ID		7168	29767
HPRD ID		01839	04237
Ensembl ID		ENSG00000140416	ENSG00000128872
Uniprot IDs		B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H7BYY1 O15513 P09493 Q6ZN40	Q9NZR1
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Actin Filament-based Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Response To Calcium Ion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Liver Development Immune Response-regulating Signaling Pathway Response To Inorganic Substance Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of ATPase Activity Negative Regulation Of Mitotic Cell Cycle Response To Mechanical Stimulus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Heart Morphogenesis Organelle Organization Regulation Of Binding Positive Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Regulation Of Nitric Oxide Biosynthetic Process Alkanesulfonate Metabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Metaphase Plate Congression Cellular Response To Potassium Ion Starvation Fc Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Epithelial Cell Proliferation Cognition Positive Regulation Of DNA Replication Mitotic Cell Cycle Response To Metal Ion Myofibril Assembly Protein Kinase D Signaling Leading Edge Cell Differentiation Metanephric Smooth Muscle Tissue Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Detection Of Nodal Flow Astrocyte Activation Renal Artery Morphogenesis	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Positive Regulation Of Heart Rate By Epinephrine Synaptic Growth At Neuromuscular Junction Muscle Contraction Movement Of Cell Or Subcellular Component Collateral Sprouting In Absence Of Injury Muscle System Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Response To Oxidative Stress Regulation Of Heart Rate By Chemical Signal Neuron Remodeling Wound Healing Actin Filament-based Process Cellular Copper Ion Homeostasis Response To Wounding Positive Regulation Of Heart Rate Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Heart Contraction Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of ATPase Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Ruffle Organization Positive Regulation Of Blood Pressure Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Positive Regulation Of Hydrolase Activity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Actin Filament Bundle Assembly Cardiac Muscle Contraction Axon Cargo Transport Mating Neuromuscular Junction Development
Tagcloud ?		abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable
Tagcloud (Difference) ?		abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable
Tagcloud (Intersection) ?