TPM1 and S100A2

Number of citations of the paper that reports this interaction (PMID 9092943)
2

Data Source:
HPRD (in vitro, in vivo)

		TPM1	S100A2
Gene Name		tropomyosin 1 (alpha)	S100 calcium binding protein A2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Sarcomere Filamentous Actin Bleb Ruffle Membrane	Cellular_component
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Muscle	Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Heart Rate By Epinephrine Movement Of Cell Or Subcellular Component Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Endothelial Cell Migration
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Mean platelet volume ( 19820697) Orofacial clefts ( 22863734) Platelet counts ( 22139419)
Protein-Protein Interactions		18 interactors: ACTB C1orf216 CAGE1 EGFR EPB41 GOLGA2 JUN KXD1 MAD1L1 PKD2 S100A2 SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4	11 interactors: FKBP4 MDM2 PPID S100A1 S100B S100P STUB1 TP53 TPM1 TPM2 TPM3
Entrez ID		7168	6273
HPRD ID		01839	01508
Ensembl ID		ENSG00000140416	ENSG00000196754
Uniprot IDs		B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H7BYY1 O15513 P09493 Q6ZN40	P29034
PDB IDs			2RGI 4DUQ
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Actin Filament-based Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Response To Calcium Ion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Liver Development Immune Response-regulating Signaling Pathway Response To Inorganic Substance Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of ATPase Activity Negative Regulation Of Mitotic Cell Cycle Response To Mechanical Stimulus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Heart Morphogenesis Organelle Organization Regulation Of Binding Positive Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Regulation Of Nitric Oxide Biosynthetic Process Alkanesulfonate Metabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Metaphase Plate Congression Cellular Response To Potassium Ion Starvation Fc Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Epithelial Cell Proliferation Cognition Positive Regulation Of DNA Replication Mitotic Cell Cycle Response To Metal Ion Myofibril Assembly Protein Kinase D Signaling Leading Edge Cell Differentiation Metanephric Smooth Muscle Tissue Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Detection Of Nodal Flow Astrocyte Activation Renal Artery Morphogenesis	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Cellular Response To UV Actin Filament-based Movement Cellular Response To Light Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Stress Response To UV Cellular Response To Radiation Response To Abiotic Stimulus Cellular Response To Oxidative Stress Muscle Contraction Regulation Of ATPase Activity Regulation Of Signal Transduction By P53 Class Mediator Muscle System Process Positive Regulation Of Transport DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Response To Antibiotic Positive Regulation Of Cellular Component Biogenesis Chaperone-mediated Protein Folding Regulation Of Protein Complex Assembly Response To Light Stimulus Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Steroid Hormone Receptor Complex Assembly Positive Regulation Of Heart Rate By Epinephrine Cellular Response To UV-C Cellular Response To Vitamin B1 Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Peptidyl-prolyl Isomerization Signal Transduction In Response To DNA Damage Response To Oxidative Stress Regulation Of Cell Cycle Arrest Mitotic DNA Damage Checkpoint Protein Complex Assembly Negative Regulation Of Macromitophagy Positive Regulation Of Voltage-gated Calcium Channel Activity
Tagcloud ?		abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable	carcinogenesis concept conflicting correlate cytoplasm debated disagree distributed downregulated dual ef equally hountis indicative indicator location middle movement nsclc operable positivity precise published seem stages substantial unfavorable varies
Tagcloud (Difference) ?		abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable	carcinogenesis concept conflicting correlate cytoplasm debated disagree distributed downregulated dual ef equally hountis indicative indicator location middle movement nsclc operable positivity precise published seem stages substantial unfavorable varies
Tagcloud (Intersection) ?