TPM1 and MAST2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		TPM1	MAST2
Description		tropomyosin 1	microtubule associated serine/threonine kinase 2
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Protein Phosphorylation Cytoskeleton Organization Regulation Of Interleukin-12 Production Intracellular Signal Transduction Spermatid Differentiation
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS		Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 27863252 32888494 19820697) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 32888494 22139419 27863252) Platelet distribution width ( 27863252 32888494) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)	Body mass index ( 25673413) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Granulocyte count ( 27863252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Red blood cell count ( 27863252 32888494) Reticulocyte count ( 32888494 27863252) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Type 2 diabetes ( 32499647)
Interacting Genes		31 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCHCR1 CDC42 CLIP4 EGFR EPB41 FGA GOLGA2 H19 IFIT3 JUN KXD1 LINC00632 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN TFPT TMOD2 TNNT1 TNNT2 TPM2 WASHC1 YEATS4	27 interacting genes: ACE2 ACTN2 APP CDHR2 DYNLL1 MXRA7 PTEN RPS27A RPS6KA1 SH3GL2 SLC34A1 SLC9A3 SMN1 SNTB2 SRPK2 STK36 SUMO2 TK1 TPM1 TPM2 TPM3 TRAF2 TRAF6 TTN USP7 VANGL2 ZNF417
Entrez ID		7168	23139
HPRD ID		01839	11294
Ensembl ID		ENSG00000140416	ENSG00000086015
Uniprot IDs		A0A0K0K1I0 A0A0S2Z4G6 A0A494BZZ2 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H0YKJ4 H7BYY1 O15513 P09493 Q6ZN40	A0A669KBJ4 Q6P0Q8
PDB IDs		3MUD 5KHT 6UT2 6X5Z 7UTI 7UTL 8EFH 8EFI 8ENC 8ZB7	2KQF 2KYL
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Identical Protein Binding Mitotic Spindle Actin Filament Organization Actin Binding Tropomyosin Binding BLOC-1 Complex Organelle Transport Along Microtubule Supramolecular Fiber Organization Cytoskeleton Actin Cytoskeleton Organization Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Troponin Complex Regulation Of Lysosome Size BORC Complex Positive Regulation Of DNA Repair Response To Calcium Ion Striated Muscle Thin Filament Microvesicle Regulation Of Endosome Size General Transcription Initiation Factor Binding Positive Regulation Of Pseudopodium Assembly Cytoplasmic Side Of Lysosomal Membrane Transport Along Microtubule Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Cycle Positive Regulation Of Epithelial Cell Proliferation Cytoskeleton-dependent Intracellular Transport Actin Filament Binding Muscle Contraction Anterograde Synaptic Vesicle Transport Regulation Of Vesicle Size Microtubule-based Transport Structural Constituent Of Cytoskeleton Regulation Of DNA Repair System Process Regulation Of Programmed Cell Death Embryonic Placenta Development Basolateral Plasma Membrane Host-mediated Perturbation Of Symbiont Process NuA4 Histone Acetyltransferase Complex Regulation Of Cellular Component Size Muscle System Process Cortical Cytoskeleton Blood Microparticle Positive Regulation Of DNA Metabolic Process Positive Regulation Of Norepinephrine Uptake	Muscle Thin Filament Tropomyosin Identical Protein Binding Structural Constituent Of Muscle Brush Border Membrane Actin Filament Actin Filament Binding Cellular Component Assembly Cytosol Apical Plasma Membrane Sarcomere Organization Enzyme Binding Muscle System Process Cell Projection Organization Plasma Membrane Bounded Cell Projection Organization Actin Cytoskeleton CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Negative Regulation Of Smooth Muscle Cell Proliferation Brush Border CD40 Receptor Complex TORC1 Signaling Positive Regulation Of JUN Kinase Activity Organelle Assembly Cytoskeletal Protein Binding Regulation Of Transport Regulation Of Biological Quality Protein Tag Activity Muscle Tissue Morphogenesis Muscle Filament Sliding Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Postsynaptic Actin Cytoskeleton Organization Actin-myosin Filament Sliding PDZ Domain Binding TOR Signaling Muscle Contraction Stress Fiber Actin Binding Response To Lead Ion Membrane Raft Postsynaptic Cytoskeleton Organization Presynapse System Process Sodium Ion Import Across Plasma Membrane Cardiac Muscle Hypertrophy Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Localization Protein Metabolic Process Cytoplasmic Side Of Plasma Membrane PML Body
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