TPM1 and TFPT

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TPM1	TFPT
Description		tropomyosin 1	TCF3 fusion partner
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane	Nucleus Nucleoplasm Cytoplasm Ino80 Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	DNA Binding Protein Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Apoptotic Process DNA Damage Response Regulation Of Chromosome Organization Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Apoptotic Signaling Pathway Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	UCH proteinases DNA Damage Recognition in GG-NER
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS		Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 27863252 32888494 19820697) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 32888494 22139419 27863252) Platelet distribution width ( 27863252 32888494) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)	Obesity-related traits ( 23251661)
Interacting Genes		31 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCHCR1 CDC42 CLIP4 EGFR EPB41 FGA GOLGA2 H19 IFIT3 JUN KXD1 LINC00632 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN TFPT TMOD2 TNNT1 TNNT2 TPM2 WASHC1 YEATS4	30 interacting genes: APP C19orf25 C4orf46 CCDC57 CCNDBP1 CDCA7L CNN1 DDIT4L DEUP1 DYDC1 EAF1 EAF2 ELL HAUS1 KRT19 LMO2 NOL3 PAWR PIM1 PIN1 PSMB1 RPGRIP1 RUNDC3A STK3 TCF3 TFIP11 TPM1 TPM2 TPM3 TRAF1
Entrez ID		7168	29844
HPRD ID		01839	10266
Ensembl ID		ENSG00000140416	ENSG00000105619
Uniprot IDs		A0A0K0K1I0 A0A0S2Z4G6 A0A494BZZ2 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H0YKJ4 H7BYY1 O15513 P09493 Q6ZN40	P0C1Z6
PDB IDs		3MUD 5KHT 6UT2 6X5Z 7UTI 7UTL 8EFH 8EFI 8ENC 8ZB7
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Identical Protein Binding Mitotic Spindle Actin Filament Organization Actin Binding Tropomyosin Binding BLOC-1 Complex Organelle Transport Along Microtubule Supramolecular Fiber Organization Cytoskeleton Actin Cytoskeleton Organization Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Troponin Complex Regulation Of Lysosome Size BORC Complex Positive Regulation Of DNA Repair Response To Calcium Ion Striated Muscle Thin Filament Microvesicle Regulation Of Endosome Size General Transcription Initiation Factor Binding Positive Regulation Of Pseudopodium Assembly Cytoplasmic Side Of Lysosomal Membrane Transport Along Microtubule Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Cycle Positive Regulation Of Epithelial Cell Proliferation Cytoskeleton-dependent Intracellular Transport Actin Filament Binding Muscle Contraction Anterograde Synaptic Vesicle Transport Regulation Of Vesicle Size Microtubule-based Transport Structural Constituent Of Cytoskeleton Regulation Of DNA Repair System Process Regulation Of Programmed Cell Death Embryonic Placenta Development Basolateral Plasma Membrane Host-mediated Perturbation Of Symbiont Process NuA4 Histone Acetyltransferase Complex Regulation Of Cellular Component Size Muscle System Process Cortical Cytoskeleton Blood Microparticle Positive Regulation Of DNA Metabolic Process Positive Regulation Of Norepinephrine Uptake	Muscle Thin Filament Tropomyosin Supramolecular Fiber Organization Transcription Elongation Factor Complex Actin Filament Super Elongation Complex Actin Filament Organization Structural Constituent Of Muscle Transcription Elongation By RNA Polymerase II Transcription Elongation Factor Activity Cytoskeleton Actin Cytoskeleton DNA-templated Transcription Elongation Regulation Of Extrinsic Apoptotic Signaling Pathway Cytoplasm Actin Binding Actin Filament Binding Microtubule Organizing Center Organization Regulation Of Transcription Elongation By RNA Polymerase II Apoptotic Process Protein Binding Cell Differentiation Involved In Embryonic Placenta Development Nuclear Speck Regulation Of DNA-templated Transcription Elongation Centriole Replication Programmed Cell Death Cell Death Actomyosin Structure Organization
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