TPM1 and EPB41

Number of citations of the paper that reports this interaction (PMID 11071908)
5

Data Source:
HPRD (in vitro)

		TPM1	EPB41
Gene Name		tropomyosin 1 (alpha)	erythrocyte membrane protein band 4.1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Sarcomere Filamentous Actin Bleb Ruffle Membrane	Nucleus Golgi Apparatus Plasma Membrane Spectrin Spectrin-associated Cytoskeleton Extrinsic Component Of Membrane Cortical Cytoskeleton Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Muscle	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Spectrin Binding
	Biological Process	In Utero Embryonic Development Positive Regulation Of Heart Rate By Epinephrine Movement Of Cell Or Subcellular Component Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Blood Circulation Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Positive Regulation Of Protein Binding
Pathways		Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases
GWAS		Mean platelet volume ( 19820697) Orofacial clefts ( 22863734) Platelet counts ( 22139419)
Protein-Protein Interactions		18 interactors: ACTB C1orf216 CAGE1 EGFR EPB41 GOLGA2 JUN KXD1 MAD1L1 PKD2 S100A2 SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4	39 interactors: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10
Entrez ID		7168	2035
HPRD ID		01839	00558
Ensembl ID		ENSG00000140416	ENSG00000159023
Uniprot IDs		B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H7BYY1 O15513 P09493 Q6ZN40	E9PEW9 P11171 Q1WWM3 Q29RX4 Q59F12
PDB IDs			1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?		Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Actin Filament-based Movement Muscle Contraction Muscle System Process Actin Filament-based Process Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Movement Of Cell Or Subcellular Component Response To Calcium Ion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Liver Development Immune Response-regulating Signaling Pathway Response To Inorganic Substance Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of ATPase Activity Negative Regulation Of Mitotic Cell Cycle Response To Mechanical Stimulus Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Heart Morphogenesis Organelle Organization Regulation Of Binding Positive Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Regulation Of Nitric Oxide Biosynthetic Process Alkanesulfonate Metabolic Process Metanephric Cortex Development Metanephric Cortical Collecting Duct Development Regulation Of Metaphase Plate Congression Cellular Response To Potassium Ion Starvation Fc Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Regulation Of Epithelial Cell Proliferation Cognition Positive Regulation Of DNA Replication Mitotic Cell Cycle Response To Metal Ion Myofibril Assembly Protein Kinase D Signaling Leading Edge Cell Differentiation Metanephric Smooth Muscle Tissue Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Detection Of Nodal Flow Astrocyte Activation Renal Artery Morphogenesis	Regulation Of Cellular Component Organization Positive Regulation Of Transport Muscle System Process Cell Development Regulation Of Establishment Of Protein Localization Regulation Of Organelle Organization Muscle Contraction Axonogenesis Movement Of Cell Or Subcellular Component Axon Guidance Axon Development System Development Regulation Of Protein Localization Cellular Component Assembly Regulation Of Cellular Localization Cell Morphogenesis Involved In Neuron Differentiation Cell Differentiation Neuron Projection Morphogenesis Anatomical Structure Development Anatomical Structure Morphogenesis Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Dopamine Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Response To External Stimulus Cell Morphogenesis Involved In Differentiation Apoptotic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of Actin Cytoskeleton Organization Programmed Cell Death Multicellular Organismal Development Muscle Filament Sliding Actin-myosin Filament Sliding Ion Homeostasis Negative Regulation Of Protein Kinase B Signaling Cell Death Death Cell Morphogenesis Neuron Projection Development Negative Regulation Of Transport Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Chemotaxis Cell Projection Morphogenesis Regulation Of Dopamine Receptor Signaling Pathway Developmental Process Regulation Of Protein Kinase B Signaling Regulation Of Protein Transport Cell Part Morphogenesis Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Cell Projection Organization
Tagcloud ?		abp1 abp1p act1 actin cap1 cap2 capping cerevisiae cytoskeleton deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable	ank1 antiglobulin appointment bilirubin cared cytoskeletal cytoskeleton damaged delays discharged e508k epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1
Tagcloud (Difference) ?		abp1 abp1p act1 actin cap1 cap2 capping cerevisiae deleterious draw extreme fimbrin inviability lacking lethal lethality null organization phenotypes physiology redundancy redundant sac6 saccharomyces surprising synthetic tropomyosin viable	ank1 antiglobulin appointment bilirubin cared cytoskeletal damaged delays discharged e508k epb42 erythrocyte incompatibility kernicterus neurologic newborn parent persisted phototherapy retesting return silico slc4a1 smear spherocytes spta1 sptb ugt1a1
Tagcloud (Intersection) ?		cytoskeleton