DOK1 and ITGB3

Number of citations of the paper that reports this interaction (PMID 12606711)
66

Data Source:
HPRD (in vitro)

		DOK1	ITGB3
Gene Name		docking protein 1, 62kDa (downstream of tyrosine kinase 1)	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Integrin Alphav-beta3 Complex Melanosome Receptor Complex Extracellular Vesicular Exosome Alphav-beta3 Integrin-vitronectin Complex
	Molecular Function	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding	Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Protein Folding Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Growth Cell Migration Platelet Activation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Regulation Of Bone Resorption Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Leukocyte Migration Negative Chemotaxis Angiogenesis Involved In Wound Healing Platelet Aggregation
Pathways		IRS-related events triggered by IGF1R Insulin receptor signalling cascade IRS activation IRS-mediated signalling Signal attenuation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events IGF1R signaling cascade PI3K Cascade PI3K Cascade Signaling by Insulin receptor	Signal transduction by L1 Axon guidance Elastic fibre formation p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation Non-integrin membrane-ECM interactions GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway Cell surface interactions at the vascular wall PECAM1 interactions Molecules associated with elastic fibres Syndecan interactions Signaling by VEGF Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Abciximab Eptifibatide Antithymocyte globulin Tirofiban
Diseases
GWAS
Protein-Protein Interactions		39 interactors: ABL1 ABL2 BCR CRK CRKL CSK ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC VAV1 YES1	40 interactors: AKT1 ANGPTL3 CAPN1 CD36 CIB1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGG FLNA FLNB FN1 ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR NID1 NUMB P2RY2 PDGFRA PDGFRB PDPK1 PECAM1 PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN
Entrez ID		1796	3690
HPRD ID		04228	01428
Ensembl ID		ENSG00000115325	ENSG00000259207
Uniprot IDs		B3KP83 B4DJN1 Q2TA81 Q99704	P05106
PDB IDs		2V76	1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4G1E 4G1M
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Locomotion Cell Migration Immune System Process Cell Surface Receptor Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Leukocyte Migration Innate Immune Response Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response Defense Response Wound Healing Blood Coagulation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Hemostasis Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Response To Wounding Cellular Response To Stimulus Single Organismal Cell-cell Adhesion Cellular Response To Organic Substance Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Activation Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Regulation Of Cell Adhesion Response To Stimulus Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling	Platelet Activation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Blood Coagulation Positive Regulation Of Cellular Component Movement Cell Adhesion Hemostasis Positive Regulation Of Locomotion Regulation Of Cell Migration Wound Healing Positive Regulation Of Phosphorylation Regulation Of Cell-substrate Adhesion Regulation Of Cell Motility Cell-substrate Adhesion Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell-substrate Adhesion Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Regulation Of Phosphorylation Cell-matrix Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Activation Blood Vessel Development Positive Regulation Of Protein Modification Process Signal Transduction Regulation Of Protein Phosphorylation Vasculature Development Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Protein Metabolic Process Cell Communication Positive Regulation Of Kinase Activity Locomotion Anatomical Structure Morphogenesis Regulation Of Protein Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Signaling Regulation Of Intracellular Signal Transduction Platelet Degranulation
Tagcloud ?		adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating	a4 acp5 apb b4 blt1 blt2 conclusionsin crac ctsk cytochemical erosion hydrolase introductionbone leukotriene leukotrienes lipoxygenase ltb4 manuscript methodswe mmp9 nfatc1 nucleated osteoclast osteoclasts pbmcs phospholipase resorbing resultsour u73122
Tagcloud (Difference) ?		adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating	a4 acp5 apb b4 blt1 blt2 conclusionsin crac ctsk cytochemical erosion hydrolase introductionbone leukotriene leukotrienes lipoxygenase ltb4 manuscript methodswe mmp9 nfatc1 nucleated osteoclast osteoclasts pbmcs phospholipase resorbing resultsour u73122
Tagcloud (Intersection) ?