DOK1 and FGR

Number of citations of the paper that reports this interaction (PMID 11071635)
19

Data Source:
HPRD (in vitro)

		DOK1	FGR
Gene Name		docking protein 1, 62kDa (downstream of tyrosine kinase 1)	FGR proto-oncogene, Src family tyrosine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway	Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Cytokine Secretion Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Cellular Response To Peptide Hormone Stimulus
Pathways		IRS-related events triggered by IGF1R Insulin receptor signalling cascade IRS activation IRS-mediated signalling Signal attenuation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events IGF1R signaling cascade PI3K Cascade PI3K Cascade Signaling by Insulin receptor	Platelet homeostasis Platelet sensitization by LDL Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		39 interactors: ABL1 ABL2 BCR CRK CRKL CSK ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC VAV1 YES1	22 interactors: ARRB1 CBL CCR3 CSK DAB2 DOK1 ERBB2 FASLG HCLS1 IKBKG INPP5D KHDRBS1 NR1I2 PTK2 SLAMF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ
Entrez ID		1796	2268
HPRD ID		04228	01288
Ensembl ID		ENSG00000115325	ENSG00000000938
Uniprot IDs		B3KP83 B4DJN1 Q2TA81 Q99704	P09769 P78453
PDB IDs		2V76
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Locomotion Cell Migration Immune System Process Cell Surface Receptor Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Leukocyte Migration Innate Immune Response Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response Defense Response Wound Healing Blood Coagulation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Hemostasis Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Response To Wounding Cellular Response To Stimulus Single Organismal Cell-cell Adhesion Cellular Response To Organic Substance Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Activation Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Regulation Of Cell Adhesion Response To Stimulus Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling	Signaling Cell Communication Positive Regulation Of Signal Transduction Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Response To Stimulus Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Endocytosis Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Organic Substance Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of Tissue Remodeling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Intracellular Transport Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transport Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Bone Resorption Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating	colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Difference) ?		adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating	colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Intersection) ?