DOK1 and PTPRH

Number of citations of the paper that reports this interaction (PMID 11278335)
5

Data Source:
HPRD (in vivo)

		DOK1	PTPRH
Gene Name		docking protein 1, 62kDa (downstream of tyrosine kinase 1)	protein tyrosine phosphatase, receptor type, H
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Cytoplasm Integral Component Of Plasma Membrane
	Molecular Function	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway	Protein Dephosphorylation Apoptotic Process Peptidyl-tyrosine Dephosphorylation
Pathways		IRS-related events triggered by IGF1R Insulin receptor signalling cascade IRS activation IRS-mediated signalling Signal attenuation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events IGF1R signaling cascade PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS
Protein-Protein Interactions		39 interactors: ABL1 ABL2 BCR CRK CRKL CSK ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC VAV1 YES1	11 interactors: BCAR1 DHPS DOK1 GHR KRTAP10-3 KRTAP10-8 LCK MAPK1 MLH1 PTK2 PXN
Entrez ID		1796	5794
HPRD ID		04228	03942
Ensembl ID		ENSG00000115325	ENSG00000080031
Uniprot IDs		B3KP83 B4DJN1 Q2TA81 Q99704	C9JCH2 Q9HD43
PDB IDs		2V76
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Locomotion Cell Migration Immune System Process Cell Surface Receptor Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Leukocyte Migration Innate Immune Response Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response Defense Response Wound Healing Blood Coagulation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Hemostasis Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Response To Wounding Cellular Response To Stimulus Single Organismal Cell-cell Adhesion Cellular Response To Organic Substance Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Activation Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Regulation Of Cell Adhesion Response To Stimulus Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling	Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Growth Hormone Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Organonitrogen Compound Enzyme Linked Receptor Protein Signaling Pathway Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification B Cell Receptor Signaling Pathway Platelet Activation Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor Peptidyl-tyrosine Phosphorylation Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Signal Complex Assembly Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Blood Coagulation Hemostasis Antigen Receptor-mediated Signaling Pathway Activation Of MAPK Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Transferase Activity
Tagcloud ?		adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?		adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?