TLE2 and PAX9

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TLE2	PAX9
Gene Name		transducin-like enhancer of split 2	paired box 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm	Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway	Transcription, DNA-templated Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Face Morphogenesis Cellular Response To Growth Factor Stimulus
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		16 interactors: BARHL1 EMX2 FOXA3 H3F3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	11 interactors: FUBP3 GTF2A1L KDM5B MSX1 NR0B2 SSX4 TLE1 TLE2 TRIP4 ZNF440 ZNF580
Entrez ID		7089	5083
HPRD ID		03025	01336
Ensembl ID		ENSG00000065717	ENSG00000198807
Uniprot IDs		B4DE62 K7EMK7 Q04725	P55771 Q2L4T1
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process System Development Organ Morphogenesis Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development RNA Biosynthetic Process Anterior/posterior Pattern Specification Cell Migration Regulation Of Binding Positive Regulation Of Transcription, DNA-templated Cell Motility Mesenchymal Cell Development Cell Differentiation Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Gene Expression Central Nervous System Development Odontogenesis Mesenchymal Cell Differentiation Face Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of BMP Signaling Pathway Nucleobase-containing Compound Metabolic Process Activation Of Meiosis Generation Of Neurons Head Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Regulation Of Cellular Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Notch Signaling Pathway Positive Regulation Of Metabolic Process BMP Signaling Pathway Involved In Heart Development Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone H3-K4 Demethylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nicotine Nail Development DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wnt Signaling Pathway Negative Regulation Of Anoikis Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Tagcloud ?			agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth
Tagcloud (Difference) ?			agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth
Tagcloud (Intersection) ?