TLE2 and BARHL1

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		TLE2	BARHL1
Name		TLE family member 2, transcriptional corepressor	BarH like homeobox 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body	Chromatin Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway	Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Midbrain Development Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Apoptotic Process Outer Hair Cell Apoptotic Process Negative Regulation Of Outer Hair Cell Apoptotic Process
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	2 interacting genes: TLE1 TLE2
Entrez ID		7089	56751
HPRD ID		03025	05554
Ensembl ID		ENSG00000065717	ENSG00000125492
Uniprot IDs		K7EMK7 Q04725	Q9BZE3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cell Differentiation Animal Organ Development Cell Population Proliferation Nucleus Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding BMP Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Odontogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Face Morphogenesis DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Midbrain Development Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Embryonic Nail Plate Morphogenesis Positive Regulation Of BMP Signaling Pathway Tube Morphogenesis Negative Regulation Of Biosynthetic Process	Transcription Regulator Complex Transcription Corepressor Activity Negative Regulation Of Canonical Wnt Signaling Pathway Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Animal Organ Morphogenesis Beta-catenin-TCF Complex Negative Regulation Of Anoikis Regulation Of Anoikis Negative Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway