PAX9 and SSX4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		PAX9	SSX4
Description		paired box 9	SSX family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Nucleus
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Cellular Response To Growth Factor Stimulus	Regulation Of DNA-templated Transcription
Pathways
Drugs
Diseases		Tooth agenesis; Hypodontia
GWAS		Breast cancer ( 23535729 29059683) Height ( 28552196) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Nonsyndromic cleft palate ( 31609978) Prostate cancer ( 29892016)
Interacting Genes		25 interacting genes: EYA2 FUBP3 GTF2A1L KDM5B KLF4 KRTAP13-3 LMO2 MSX1 MYLIP NR0B2 PFDN5 PLAGL2 SFN SLAIN1 SSX4 TEPSIN TLE1 TLE2 TRIP13 TRIP4 VPS37C WWOX ZNF343 ZNF440 ZNF580	6 interacting genes: C14orf119 FLACC1 HIF1A LZTR1 PAX9 XBP1
Entrez ID		5083	6759
HPRD ID		01336	02266
Ensembl ID		ENSG00000198807	ENSG00000268009
Uniprot IDs		P55771 Q2L4T1	O60224
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Wnt Signaling Pathway Transcription Coactivator Activity Transcription By RNA Polymerase II Animal Organ Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Skin Barrier Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Regulation Of Meiotic Nuclear Division Regulation Of Wnt Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Canonical Wnt Signaling Pathway RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Coated Vesicle Membrane Skin Epidermis Development Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway Transcription Coregulator Binding	Glandular Epithelial Cell Maturation Columnar/cuboidal Epithelial Cell Maturation Epithelial Cell Maturation RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Elastin Metabolic Process Carbohydrate Homeostasis Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Glucose Homeostasis Hemoglobin Biosynthetic Process Vascular Endothelial Growth Factor Production Developmental Maturation Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Autophagy Negative Regulation Of Intracellular Signal Transduction B-1 B Cell Homeostasis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Cis-regulatory Region Sequence-specific DNA Binding Motile Cilium Cell Maturation Regulation Of TOR Signaling Neural Fold Elevation Formation Intestinal Epithelial Cell Maturation Positive Regulation Of Angiogenesis Positive Regulation Of Epithelial Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Histone Deacetylase Binding RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Vasculature Development Tissue Development Intracellular Glucose Homeostasis Positive Regulation Of Chemokine-mediated Signaling Pathway Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Vascular Wound Healing Response To Insulin-like Growth Factor Stimulus Cellular Response To Fructose Stimulus Epithelial Cell Maturation Involved In Salivary Gland Development Positive Regulation Of Lactation Positive Regulation Of Protein Acetylation Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Outer Dense Fiber Iris Morphogenesis Intracellular Oxygen Homeostasis Negative Regulation Of Mesenchymal Cell Apoptotic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Hormone Biosynthetic Process Connective Tissue Replacement
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