PAX9 and SSX4

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PAX9	SSX4
Gene Name		paired box 9	synovial sarcoma, X breakpoint 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding	Nucleic Acid Binding
	Biological Process	Transcription, DNA-templated Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Face Morphogenesis Cellular Response To Growth Factor Stimulus	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		11 interactors: FUBP3 GTF2A1L KDM5B MSX1 NR0B2 SSX4 TLE1 TLE2 TRIP4 ZNF440 ZNF580	4 interactors: HIF1A LZTR1 PAX9 XBP1
Entrez ID		5083	6759
HPRD ID		01336	02266
Ensembl ID		ENSG00000198807	ENSG00000204645
Uniprot IDs		P55771 Q2L4T1	A8MYD4 O60224
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Regulation Of Cellular Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Notch Signaling Pathway Positive Regulation Of Metabolic Process BMP Signaling Pathway Involved In Heart Development Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone H3-K4 Demethylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nicotine Nail Development DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wnt Signaling Pathway Negative Regulation Of Anoikis Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Epithelial Cell Maturation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Regulation Of TOR Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Anatomical Structure Morphogenesis Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Serotonin Secretion, Neurotransmission Neural Fold Elevation Formation Response To Insulin-like Growth Factor Stimulus Transcription From RNA Polymerase II Promoter Cell Maturation Digestive System Development Positive Regulation Of Epithelial Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Involved In Salivary Gland Development Elastin Metabolic Process Regulation Of Organ Morphogenesis Positive Regulation Of Protein Secretion Cellular Response To Oxidative Stress Glucose Homeostasis Epithelial Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Intestinal Epithelial Cell Maturation Connective Tissue Development Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Serotonin Secretion Regulation Of Epithelial Cell Proliferation Axon Transport Of Mitochondrion Hemoglobin Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Wound Healing Involved In Inflammatory Response Oxygen Homeostasis Negative Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Interleukin-6 Secretion Cellular Response To Fructose Stimulus Positive Regulation Of Secretion
Tagcloud ?		agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth	applicable associates behind brings cofactors counteract dysregulation egr1 h3k27 hdac highlights implicate m3 oncogenesis opposing polycomb reactivates repressed reverts romidepsin sarcoma snf ss18 ssx1 ssx2 swi synovial trimethylation
Tagcloud (Difference) ?		agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth	applicable associates behind brings cofactors counteract dysregulation egr1 h3k27 hdac highlights implicate m3 oncogenesis opposing polycomb reactivates repressed reverts romidepsin sarcoma snf ss18 ssx1 ssx2 swi synovial trimethylation
Tagcloud (Intersection) ?