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TLE2 and HES1
Number of citations of the paper that reports this interaction (PMID
9874198
)
26
Data Source:
BioGRID
(pull down, two hybrid)
TLE2
HES1
Gene Name
transducin-like enhancer of split 2
hes family bHLH transcription factor 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Transcription Corepressor Activity
Protein Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Sequence-specific DNA Binding
Chaperone Binding
N-box Binding
Biological Process
Transcription, DNA-templated
Signal Transduction
Notch Signaling Pathway
Organ Morphogenesis
Wnt Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Liver Development
Embryonic Heart Tube Morphogenesis
Outflow Tract Morphogenesis
Regulation Of Secondary Heart Field Cardioblast Proliferation
Ventricular Septum Development
Transcription From RNA Polymerase II Promoter
Protein Complex Assembly
Cell Adhesion
Notch Signaling Pathway
Smoothened Signaling Pathway
STAT Protein Import Into Nucleus
Nervous System Development
Positive Regulation Of Cell Proliferation
Cell Migration
Telencephalon Development
Midbrain-hindbrain Boundary Morphogenesis
Oculomotor Nerve Development
Trochlear Nerve Development
Hindbrain Morphogenesis
Forebrain Radial Glial Cell Differentiation
Adenohypophysis Development
Lung Development
Positive Regulation Of BMP Signaling Pathway
Midbrain Development
Endocrine Pancreas Development
Somatic Stem Cell Maintenance
Ascending Aorta Morphogenesis
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Auditory Receptor Cell Fate Determination
Positive Regulation Of DNA Binding
Regulation Of Fat Cell Differentiation
Negative Regulation Of Auditory Receptor Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Mitotic Cell Cycle, Embryonic
Lateral Inhibition
Positive Regulation Of JAK-STAT Cascade
Cell Maturation
Thymus Development
Cell Morphogenesis Involved In Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Oligodendrocyte Differentiation
Artery Morphogenesis
Regulation Of Timing Of Neuron Differentiation
Negative Regulation Of Glial Cell Proliferation
Ventricular Septum Morphogenesis
Ureteric Bud Morphogenesis
Labyrinthine Layer Blood Vessel Development
Common Bile Duct Development
Negative Regulation Of Stomach Neuroendocrine Cell Differentiation
Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis
Pharyngeal Arch Artery Morphogenesis
Glomerulus Vasculature Development
Comma-shaped Body Morphogenesis
S-shaped Body Morphogenesis
Renal Interstitial Fibroblast Development
Metanephric Nephron Tubule Morphogenesis
Cochlea Development
Vascular Smooth Muscle Cell Development
Neuronal Stem Cell Maintenance
Negative Regulation Of Pancreatic A Cell Differentiation
Negative Regulation Of Stem Cell Differentiation
Negative Regulation Of Pro-B Cell Differentiation
Negative Regulation Of Forebrain Neuron Differentiation
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
APC truncation mutants have impaired AXIN binding
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
RNF mutants show enhanced WNT signaling and proliferation
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by NOTCH1 in Cancer
truncations of AMER1 destabilize the destruction complex
FBXW7 Mutants and NOTCH1 in Cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
repression of WNT target genes
NOTCH1 Intracellular Domain Regulates Transcription
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by WNT in cancer
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Signaling by NOTCH
NOTCH2 intracellular domain regulates transcription
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
NOTCH1 Intracellular Domain Regulates Transcription
Signaling by NOTCH2
Regulation of beta-cell development
Signaling by NOTCH1
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
16 interactors:
BARHL1
EMX2
FOXA3
H3F3A
HES1
HMGB1
LEF1
MSX1
MSX2
PAX9
PRDM1
RUNX1
TLE1
TLX3
UTY
VENTX
33 interactors:
APCS
APH1A
ASGR2
CSNK1E
FANCA
FANCE
FANCF
FANCG
FANCL
FHL1
FOXG1
GAPDH
HDAC6
HES6
HEY2
HMGB1
HMGCL
ID1
ID2
ID3
ID4
JAK2
LTBR
NR4A1
NUDT3
PRKCA
PTK2
SIRT1
STAT3
TLE1
TLE2
UBQLN1
YWHAB
Entrez ID
7089
3280
HPRD ID
03025
00770
Ensembl ID
ENSG00000065717
ENSG00000114315
Uniprot IDs
B4DE62
K7EMK7
Q04725
Q14469
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of DNA Binding
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Multicellular Organismal Development
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
System Development
Organ Morphogenesis
Developmental Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
RNA Biosynthetic Process
Anterior/posterior Pattern Specification
Cell Migration
Regulation Of Binding
Positive Regulation Of Transcription, DNA-templated
Cell Motility
Mesenchymal Cell Development
Cell Differentiation
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Embryonic Nail Plate Morphogenesis
Gene Expression
Central Nervous System Development
Odontogenesis
Mesenchymal Cell Differentiation
Face Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of BMP Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Activation Of Meiosis
Generation Of Neurons
Head Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
System Development
Organ Development
Multicellular Organismal Development
Response To Stress
Anatomical Structure Development
Regulation Of Cell Death
Negative Regulation Of Biosynthetic Process
Developmental Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Apoptotic Process
Response To Stimulus
Rhythmic Process
Cellular Metabolic Process
Cellular Response To Stimulus
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cell Differentiation
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Nitrogen Compound Metabolic Process
Circadian Rhythm
Regulation Of DNA Binding
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Response To Stress
Negative Regulation Of Cell Differentiation
Apoptotic Process
Negative Regulation Of DNA Binding
Regulation Of Cell Differentiation
Programmed Cell Death
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cell Death
Death
Regulation Of Osteoblast Differentiation
Positive Regulation Of Apoptotic Process
DNA Repair
Response To Growth Factor
Anatomical Structure Morphogenesis
Regulation Of Cell Proliferation
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Response To External Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Gene Expression
Negative Regulation Of Cell Death
Tagcloud
?
alterations
anatomic
astrocytoma
astrocytomas
biology
braf
grade
hey1
hey2
implicated
inhibiting
interference
much
needed
neoplastic
notch
notch1
notch2
overexpressed
pa
pas
pediatric
pilocytic
res186
res259
secretase
tumorigenesis
variable
viable
Tagcloud (Difference)
?
alterations
anatomic
astrocytoma
astrocytomas
biology
braf
grade
hey1
hey2
implicated
inhibiting
interference
much
needed
neoplastic
notch
notch1
notch2
overexpressed
pa
pas
pediatric
pilocytic
res186
res259
secretase
tumorigenesis
variable
viable
Tagcloud (Intersection)
?