Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
TLE2 and HMGB1
Number of citations of the paper that reports this interaction (PMID
11748221
)
27
Data Source:
HPRD
(in vitro)
TLE2
HMGB1
Gene Name
transducin-like enhancer of split 2
high mobility group box 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Cell Surface
Transcriptional Repressor Complex
Molecular Function
Transcription Corepressor Activity
Protein Binding
Chromatin Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Cytokine Activity
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Chemoattractant Activity
Poly(A) RNA Binding
RAGE Receptor Binding
Repressing Transcription Factor Binding
Biological Process
Transcription, DNA-templated
Signal Transduction
Notch Signaling Pathway
Organ Morphogenesis
Wnt Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Myeloid Dendritic Cell Activation
Dendritic Cell Chemotaxis
Inflammatory Response To Antigenic Stimulus
DNA Topological Change
Base-excision Repair, DNA Ligation
Apoptotic DNA Fragmentation
DNA Recombination
Chromatin Remodeling
Regulation Of Transcription From RNA Polymerase II Promoter
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Neuron Projection Development
V(D)J Recombination
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of DNA Binding
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Chemotaxis
DNA Ligation Involved In DNA Repair
Negative Regulation Of Apoptotic Cell Clearance
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
APC truncation mutants have impaired AXIN binding
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
RNF mutants show enhanced WNT signaling and proliferation
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by NOTCH1 in Cancer
truncations of AMER1 destabilize the destruction complex
FBXW7 Mutants and NOTCH1 in Cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
repression of WNT target genes
NOTCH1 Intracellular Domain Regulates Transcription
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by WNT in cancer
Toll Like Receptor 7/8 (TLR7/8) Cascade
RIP-mediated NFkB activation via ZBP1
Toll Like Receptor TLR6:TLR2 Cascade
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Activation of DNA fragmentation factor
Toll Like Receptor 5 (TLR5) Cascade
ZBP1(DAI) mediated induction of type I IFNs
Programmed Cell Death
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Advanced glycosylation endproduct receptor signaling
Innate Immune System
TRIF-mediated TLR3/TLR4 signaling
Cytosolic sensors of pathogen-associated DNA
Apoptotic execution phase
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Apoptosis induced DNA fragmentation
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
TRAF6 mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
MRI atrophy measures (
21116278
)
Protein-Protein Interactions
16 interactors:
BARHL1
EMX2
FOXA3
H3F3A
HES1
HMGB1
LEF1
MSX1
MSX2
PAX9
PRDM1
RUNX1
TLE1
TLX3
UTY
VENTX
73 interactors:
AES
AGER
AGTRAP
AR
ATOH1
C14orf1
CASP3
CDK1
CEBPB
CREBBP
CRMP1
CSNK1A1
CTCF
CUX1
DNM2
DNMT1
ERF
FOXA3
FOXC1
GTF2A1
HES1
HMGA1
HNRNPK
HOXB1
HOXB3
HOXC6
HOXD10
HOXD11
HOXD3
HOXD8
HOXD9
HR
IRF2
LRIF1
MECP2
MNT
NCAN
NEUROD6
NFKB1
NR3C1
PGR
PLAT
PLG
POU5F1
PPP2R3A
PRKCA
PRKDC
PSEN1
PTPRZ1
RAD23B
RAG1
RASSF4
RB1
RBPJ
RELA
RFX1
SIX5
SOX18
TAF1
TBP
TERF2
TERF2IP
TFE3
TGIF1
TLE1
TLE2
TLR2
TLR4
TP53
TP73
UNC119
ZFP36
ZNF24
Entrez ID
7089
3146
HPRD ID
03025
01228
Ensembl ID
ENSG00000065717
ENSG00000189403
Uniprot IDs
B4DE62
K7EMK7
Q04725
P09429
Q5T7C4
PDB IDs
2LY4
2YRQ
Enriched GO Terms of Interacting Partners
?
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of DNA Binding
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Multicellular Organismal Development
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
System Development
Organ Morphogenesis
Developmental Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
RNA Biosynthetic Process
Anterior/posterior Pattern Specification
Cell Migration
Regulation Of Binding
Positive Regulation Of Transcription, DNA-templated
Cell Motility
Mesenchymal Cell Development
Cell Differentiation
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Embryonic Nail Plate Morphogenesis
Gene Expression
Central Nervous System Development
Odontogenesis
Mesenchymal Cell Differentiation
Face Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of BMP Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Activation Of Meiosis
Generation Of Neurons
Head Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Gene Expression
Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
RNA Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Metabolic Process
Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Cellular Metabolic Process
Multicellular Organismal Development
Regulation Of Cellular Process
System Development
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Anatomical Structure Development
Developmental Process
Anatomical Structure Morphogenesis
Cell Differentiation
Chordate Embryonic Development
Embryo Development Ending In Birth Or Egg Hatching
Embryo Development
Anterior/posterior Pattern Specification
Regulation Of Cell Differentiation
Pattern Specification Process
Tagcloud
?
1racp
abilities
analysed
ankylosing
asdas
basdai
basfi
bath
besides
box
chromosomal
compare
correlations
crp
elisa
erythrocytesedimentationrate
esr
from71
healthy
index
mobility
pbmcs
rage
remarkably
spondylitis
surface
tlr2
tlr4
untreated
Tagcloud (Difference)
?
1racp
abilities
analysed
ankylosing
asdas
basdai
basfi
bath
besides
box
chromosomal
compare
correlations
crp
elisa
erythrocytesedimentationrate
esr
from71
healthy
index
mobility
pbmcs
rage
remarkably
spondylitis
surface
tlr2
tlr4
untreated
Tagcloud (Intersection)
?