PAX9 and ZNF440

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PAX9	ZNF440
Gene Name		paired box 9	zinc finger protein 440
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding	DNA Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Face Morphogenesis Cellular Response To Growth Factor Stimulus	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways			Generic Transcription Pathway
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		11 interactors: FUBP3 GTF2A1L KDM5B MSX1 NR0B2 SSX4 TLE1 TLE2 TRIP4 ZNF440 ZNF580	12 interactors: KRTAP10-1 KRTAP10-9 KRTAP4-12 MAP4K5 MDFI MID2 MTUS2 NOTCH2NL PAX9 PJA1 TRAF1 XBP1
Entrez ID		5083	126070
HPRD ID		01336	11718
Ensembl ID		ENSG00000198807	ENSG00000171295
Uniprot IDs		P55771 Q2L4T1	Q8IYI8
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Regulation Of Cellular Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Notch Signaling Pathway Positive Regulation Of Metabolic Process BMP Signaling Pathway Involved In Heart Development Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone H3-K4 Demethylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nicotine Nail Development DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wnt Signaling Pathway Negative Regulation Of Anoikis Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Activation Of JUN Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Negative Regulation Of RNA Biosynthetic Process Regulation Of JUN Kinase Activity JNK Cascade Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Protein Kinase Activity Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress-activated MAPK Cascade Positive Regulation Of Transferase Activity Stress-activated Protein Kinase Signaling Cascade Cell Differentiation Involved In Salivary Gland Development Positive Regulation Of JNK Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Signal Transduction Activation Of MAPK Activity Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of JNK Cascade Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Protein Phosphorylation Regulation Of Protein Import Into Nucleus Regulation Of Protein Kinase Activity Regulation Of Signaling Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Serotonin Secretion Regulation Of Intracellular Signal Transduction Regulation Of Organ Morphogenesis Regulation Of Stress-activated MAPK Cascade Regulation Of Kinase Activity Regulation Of Protein Localization To Nucleus Positive Regulation Of MAP Kinase Activity Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Hepatocyte Proliferation Cellular Response To Fructose Stimulus Positive Regulation Of Interleukin-6 Secretion Positive Regulation Of Phosphorylation MAPK Cascade Cellular Response To Laminar Fluid Shear Stress
Tagcloud ?		agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth
Tagcloud (Difference) ?		agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth
Tagcloud (Intersection) ?