PAX9 and ZNF580

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		PAX9	ZNF580
Gene Name		paired box 9	zinc finger protein 580
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Face Morphogenesis Cellular Response To Growth Factor Stimulus	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chemotaxis Inflammatory Response Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-8 Production Cellular Response To Hydrogen Peroxide
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		11 interactors: FUBP3 GTF2A1L KDM5B MSX1 NR0B2 SSX4 TLE1 TLE2 TRIP4 ZNF440 ZNF580	6 interactors: ARHGEF6 PAX9 RAD54B SH3GL2 TSC22D4 XBP1
Entrez ID		5083	51157
HPRD ID		01336	18353
Ensembl ID		ENSG00000198807	ENSG00000213015
Uniprot IDs		P55771 Q2L4T1	Q9UK33
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Regulation Of Cellular Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Activation Of Meiosis Notch Signaling Pathway Positive Regulation Of Metabolic Process BMP Signaling Pathway Involved In Heart Development Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Histone H3-K4 Demethylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nicotine Nail Development DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wnt Signaling Pathway Negative Regulation Of Anoikis Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation	Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development Response To Insulin-like Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Involved In Salivary Gland Development Cellular Response To Organic Substance Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Serotonin Secretion Neurotrophin Signaling Pathway Response To Organic Substance Positive Regulation Of Hepatocyte Proliferation Cellular Response To Fructose Stimulus Positive Regulation Of Interleukin-6 Secretion Response To Stimulus Negative Regulation Of Transcription, DNA-templated Cellular Response To Laminar Fluid Shear Stress Serotonin Transport Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Immunoglobulin Secretion Exocrine Pancreas Development Cellular Triglyceride Homeostasis Response To Fructose Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Hepatocyte Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Myotube Differentiation Negative Regulation Of Biosynthetic Process Fatty Acid Homeostasis Regulation Of Immunoglobulin Secretion Cellular Response To Fluid Shear Stress Positive Regulation Of B Cell Differentiation Response To Laminar Fluid Shear Stress Endothelial Cell Proliferation Cellular Response To Stress Cellular Response To Antibiotic Negative Regulation Of Striated Muscle Cell Differentiation Response To Stress Epithelial Cell Maturation Positive Regulation Of TOR Signaling
Tagcloud ?		agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth
Tagcloud (Difference) ?		agenesis c2c12 causative clarify convenient electrophoretic hard homeodomain hypodontia illustrates impair l205r lesser leu205 leu205arg mesenchymal msx1 mutational myod nonsyndromic oligodontia oligonucleotide pivotal sampled substitutions t174i thr174 thr174ile tooth
Tagcloud (Intersection) ?