PAX9 and TLE1

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		PAX9	TLE1
Description		paired box 9	TLE family member 1, transcriptional corepressor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Cellular Response To Growth Factor Stimulus	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis
Pathways			Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases		Tooth agenesis; Hypodontia
GWAS		Breast cancer ( 23535729 29059683) Height ( 28552196) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Nonsyndromic cleft palate ( 31609978) Prostate cancer ( 29892016)	Appendicular lean mass ( 33097823) Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 32499647 30718926 30297969 30054458 28869590 26818947 24509480) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Interacting Genes		25 interacting genes: EYA2 FUBP3 GTF2A1L KDM5B KLF4 KRTAP13-3 LMO2 MSX1 MYLIP NR0B2 PFDN5 PLAGL2 SFN SLAIN1 SSX4 TEPSIN TLE1 TLE2 TRIP13 TRIP4 VPS37C WWOX ZNF343 ZNF440 ZNF580	83 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TSC22D1 UTY ZFP64
Entrez ID		5083	7088
HPRD ID		01336	02557
Ensembl ID		ENSG00000198807	ENSG00000196781
Uniprot IDs		P55771 Q2L4T1	B4DEF9 Q04724 Q59EF7
PDB IDs			1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Wnt Signaling Pathway Transcription Coactivator Activity Transcription By RNA Polymerase II Animal Organ Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Skin Barrier Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Regulation Of Meiotic Nuclear Division Regulation Of Wnt Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Canonical Wnt Signaling Pathway RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Coated Vesicle Membrane Skin Epidermis Development Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway Transcription Coregulator Binding	Sequence-specific Double-stranded DNA Binding Chromatin Developmental Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Cell Differentiation DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regionalization Negative Regulation Of DNA-templated Transcription Cellular Developmental Process Negative Regulation Of RNA Biosynthetic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Mesenchymal Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Transcription Corepressor Binding
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