PAX9 and FUBP3

Number of citations: 106 (PubMedID 35140242)
Data Source: BioGRID (proximity labelling technology, two hybrid)

		PAX9	FUBP3
Name		paired box 9	far upstream element binding protein 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytoplasm Ribosome Membrane Neuronal Cell Body Dendritic Shaft
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Cellular Response To Growth Factor Stimulus	DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Intracellular MRNA Localization Positive Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Diseases		Tooth agenesis; Hypodontia	None
GWAS		Breast cancer ( 23535729 29059683 ) Height ( 28552196 ) Lobe attachment (rater scored) ( 29198719 ) Lobe attachment (rater-scored or self-reported) ( 29198719 ) Nonsyndromic cleft palate ( 31609978 ) Prostate cancer ( 29892016 )	Anthropometric traits ( 30166351 ) Anthropometric traits (multi-trait analysis) ( 30166351 ) Appendicular lean mass ( 33097823 ) Bone mineral density (paediatric, lower limb) ( 24945404 ) Bone mineral density (paediatric, total body less head) ( 24945404 ) Estimated glomerular filtration rate ( 31152163 ) Femoral neck bone mineral density ( 22504420 29499414 ) Fractures ( 30158200 ) Height ( 18391950 20881960 23563607 25282103 28552196 31562340 ) Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		25 interacting genes: EYA2 FUBP3 GTF2A1L KDM5B KLF4 KRTAP13-3 LMO2 MSX1 MYLIP NR0B2 PFDN5 PLAGL2 SFN SLAIN1 SSX4 TEPSIN TLE1 TLE2 TRIP13 TRIP4 VPS37C WWOX ZNF343 ZNF440 ZNF580	14 interacting genes: APP ATXN1 CALCOCO2 CEBPA LINC00624 MARCHF8 OGT PAX9 PTEN QKI RBPMS2 RNF10 SSX1 XBP1
Entrez ID		5083	8939
HPRD ID		01336	04640
Ensembl ID		ENSG00000198807	ENSG00000107164
Uniprot IDs		P55771 Q2L4T1	Q96I24
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Wnt Signaling Pathway Transcription Coactivator Activity Transcription By RNA Polymerase II Animal Organ Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Skin Barrier Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Regulation Of Meiotic Nuclear Division Regulation Of Wnt Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Canonical Wnt Signaling Pathway RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Coated Vesicle Membrane Skin Epidermis Development Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway Transcription Coregulator Binding	Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of RNA Metabolic Process Regulation Of Nervous System Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Catabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Developmental Maturation Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Development Learning Or Memory Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Gliogenesis Positive Regulation Of Lipid Biosynthetic Process Cognition Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Myelination Regulation Of Macromolecule Biosynthetic Process Memory Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process