PAX9 and NR0B2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		PAX9	NR0B2
Description		paired box 9	nuclear receptor subfamily 0 group B member 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Nuclear Receptor Binding Protein Domain Specific Binding Protein Homodimerization Activity Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Transcription Regulator Inhibitor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Cellular Response To Growth Factor Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Circadian Rhythm Cholesterol Metabolic Process Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Animal Organ Regeneration Positive Regulation Of Insulin Secretion Circadian Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity Response To Ethanol Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process
Pathways			Nuclear Receptor transcription pathway
Drugs
Diseases		Tooth agenesis; Hypodontia
GWAS		Breast cancer ( 23535729 29059683) Height ( 28552196) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Nonsyndromic cleft palate ( 31609978) Prostate cancer ( 29892016)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) HDL cholesterol ( 24097068) LDL cholesterol ( 24097068) Triglycerides ( 24097068)
Interacting Genes		25 interacting genes: EYA2 FUBP3 GTF2A1L KDM5B KLF4 KRTAP13-3 LMO2 MSX1 MYLIP NR0B2 PFDN5 PLAGL2 SFN SLAIN1 SSX4 TEPSIN TLE1 TLE2 TRIP13 TRIP4 VPS37C WWOX ZNF343 ZNF440 ZNF580	51 interacting genes: AR CHRD CIDEC DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 GPSM3 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 ID2 IL3RA NCOA3 NEUROD1 NR1H2 NR1H3 NR1I2 NR1I3 NR3C1 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 VDR XBP1 ZAP70 ZMYND10
Entrez ID		5083	8431
HPRD ID		01336	05219
Ensembl ID		ENSG00000198807	ENSG00000131910
Uniprot IDs		P55771 Q2L4T1	Q15466
PDB IDs			1YUC 2Q3Y 2Z4J 4DOR 4ONI 5UFS 6W9M 7YXC 7YXD 7YXN 7YXO 7YXP 7YXR
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Wnt Signaling Pathway Transcription Coactivator Activity Transcription By RNA Polymerase II Animal Organ Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Skin Barrier Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Regulation Of Meiotic Nuclear Division Regulation Of Wnt Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Canonical Wnt Signaling Pathway RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Coated Vesicle Membrane Skin Epidermis Development Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway Transcription Coregulator Binding	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Retinoic Acid Receptor Signaling Pathway Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Binding Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Nucleoplasm DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Developmental Process Cell Differentiation MRNA Transcription DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process
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