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TLE2 and UTY
Number of citations of the paper that reports this interaction (PMID
9854018
)
19
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid, in vitro)
TLE2
UTY
Gene Name
transducin-like enhancer of split 2
ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Nucleus
Molecular Function
Transcription Corepressor Activity
Protein Binding
Metal Ion Binding
Dioxygenase Activity
Histone Demethylase Activity (H3-K27 Specific)
Biological Process
Transcription, DNA-templated
Signal Transduction
Notch Signaling Pathway
Organ Morphogenesis
Wnt Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Gene Expression
Oxidation-reduction Process
Histone H3-K27 Demethylation
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
APC truncation mutants have impaired AXIN binding
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
RNF mutants show enhanced WNT signaling and proliferation
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by NOTCH1 in Cancer
truncations of AMER1 destabilize the destruction complex
FBXW7 Mutants and NOTCH1 in Cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
repression of WNT target genes
NOTCH1 Intracellular Domain Regulates Transcription
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
16 interactors:
BARHL1
EMX2
FOXA3
H3F3A
HES1
HMGB1
LEF1
MSX1
MSX2
PAX9
PRDM1
RUNX1
TLE1
TLX3
UTY
VENTX
3 interactors:
PRDX2
TLE1
TLE2
Entrez ID
7089
7404
HPRD ID
03025
02451
Ensembl ID
ENSG00000065717
ENSG00000183878
Uniprot IDs
B4DE62
K7EMK7
Q04725
E1NZ93
E1U198
E1U1M3
E1U1M9
F4MH27
F4MH29
F4MH30
F4MH31
F4MH32
F4MH35
F4MH36
F4MH40
F4MH46
F4MH47
F4MH50
F4MH51
F4MH58
F4MH60
F4MH62
F4MH91
F4MH92
F5GWV3
F5H3N7
O14607
PDB IDs
3ZLI
3ZPO
Enriched GO Terms of Interacting Partners
?
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of DNA Binding
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Multicellular Organismal Development
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
System Development
Organ Morphogenesis
Developmental Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
RNA Biosynthetic Process
Anterior/posterior Pattern Specification
Cell Migration
Regulation Of Binding
Positive Regulation Of Transcription, DNA-templated
Cell Motility
Mesenchymal Cell Development
Cell Differentiation
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Embryonic Nail Plate Morphogenesis
Gene Expression
Central Nervous System Development
Odontogenesis
Mesenchymal Cell Differentiation
Face Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of BMP Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Activation Of Meiosis
Generation Of Neurons
Head Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Notch Signaling Pathway
Negative Regulation Of Wnt Signaling Pathway
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Negative Regulation Of Anoikis
Hydrogen Peroxide Catabolic Process
Regulation Of Anoikis
Removal Of Superoxide Radicals
Cellular Response To Superoxide
Response To Superoxide
Response To Oxygen Radical
Hydrogen Peroxide Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Negative Regulation Of Cell Death
Superoxide Metabolic Process
Organ Morphogenesis
Negative Regulation Of Signal Transduction
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Signaling
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Regulation Of Apoptotic Process
Regulation Of Cell Death
Cellular Response To Reactive Oxygen Species
Reactive Oxygen Species Metabolic Process
Tagcloud
?
2gamma
chromosome
dffry
dmd
encode
escape
escapes
eutherian
homologue
homologues
identity
inactivation
kangaroo
maps
metatherian
primates
retroposon
retroposons
shed
simian
smcy
spermatogenesis
sxrb
ube1y
ubiquitously
xp21
zfy1
zfy2
Tagcloud (Difference)
?
2gamma
chromosome
dffry
dmd
encode
escape
escapes
eutherian
homologue
homologues
identity
inactivation
kangaroo
maps
metatherian
primates
retroposon
retroposons
shed
simian
smcy
spermatogenesis
sxrb
ube1y
ubiquitously
xp21
zfy1
zfy2
Tagcloud (Intersection)
?