PAX9 and TLE2

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		PAX9	TLE2
Name		paired box 9	TLE family member 2, transcriptional corepressor
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Cellular Response To Growth Factor Stimulus	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		None	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Diseases		Tooth agenesis; Hypodontia	None
GWAS		Breast cancer ( 23535729 29059683 ) Height ( 28552196 ) Lobe attachment (rater scored) ( 29198719 ) Lobe attachment (rater-scored or self-reported) ( 29198719 ) Nonsyndromic cleft palate ( 31609978 ) Prostate cancer ( 29892016 )	No GWAS studies recorded
Interacting Genes		25 interacting genes: EYA2 FUBP3 GTF2A1L KDM5B KLF4 KRTAP13-3 LMO2 MSX1 MYLIP NR0B2 PFDN5 PLAGL2 SFN SLAIN1 SSX4 TEPSIN TLE1 TLE2 TRIP13 TRIP4 VPS37C WWOX ZNF343 ZNF440 ZNF580	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		5083	7089
HPRD ID		01336	03025
Ensembl ID		ENSG00000198807	ENSG00000065717
Uniprot IDs		P55771 Q2L4T1	K7EMK7 Q04725
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Wnt Signaling Pathway Transcription Coactivator Activity Transcription By RNA Polymerase II Animal Organ Morphogenesis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Skin Barrier Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Apoptotic Signaling Pathway Sequence-specific Double-stranded DNA Binding Regulation Of Meiotic Nuclear Division Regulation Of Wnt Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly Negative Regulation Of Canonical Wnt Signaling Pathway RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Coated Vesicle Membrane Skin Epidermis Development Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway Transcription Coregulator Binding	Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cell Differentiation Animal Organ Development Cell Population Proliferation Nucleus Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding BMP Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Odontogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Face Morphogenesis DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Midbrain Development Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Embryonic Nail Plate Morphogenesis Positive Regulation Of BMP Signaling Pathway Tube Morphogenesis Negative Regulation Of Biosynthetic Process