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TLE2 and PRDM1
Number of citations of the paper that reports this interaction (PMID
9887105
)
60
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
TLE2
PRDM1
Gene Name
transducin-like enhancer of split 2
PR domain containing 1, with ZNF domain
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Nucleus
Cytoplasm
Molecular Function
Transcription Corepressor Activity
Protein Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Methyltransferase Activity
Histone Deacetylase Binding
Metal Ion Binding
Biological Process
Transcription, DNA-templated
Signal Transduction
Notch Signaling Pathway
Organ Morphogenesis
Wnt Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Maternal Placenta Development
Transcription, DNA-templated
Germ Cell Development
Post-embryonic Development
Positive Regulation Of Gene Expression
Negative Regulation Of B Cell Proliferation
Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Methylation
Eye Photoreceptor Cell Development
Cell Fate Commitment
Positive Regulation Of B Cell Differentiation
Intestinal Epithelial Cell Development
Trophoblast Giant Cell Differentiation
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
APC truncation mutants have impaired AXIN binding
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
RNF mutants show enhanced WNT signaling and proliferation
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by NOTCH1 in Cancer
truncations of AMER1 destabilize the destruction complex
FBXW7 Mutants and NOTCH1 in Cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
repression of WNT target genes
NOTCH1 Intracellular Domain Regulates Transcription
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) (
23648065
)
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) (
23648065
)
Crohn's disease (
21102463
)
Systemic lupus erythematosus (
23273568
19838193
)
Protein-Protein Interactions
16 interactors:
BARHL1
EMX2
FOXA3
H3F3A
HES1
HMGB1
LEF1
MSX1
MSX2
PAX9
PRDM1
RUNX1
TLE1
TLX3
UTY
VENTX
9 interactors:
AES
ATXN1
HIST1H1A
HIST2H3A
IRF4
KDM1A
PIAS1
TLE1
TLE2
Entrez ID
7089
639
HPRD ID
03025
04572
Ensembl ID
ENSG00000065717
ENSG00000057657
Uniprot IDs
B4DE62
K7EMK7
Q04725
B4DW27
O75626
PDB IDs
3DAL
Enriched GO Terms of Interacting Partners
?
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of DNA Binding
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Multicellular Organismal Development
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
System Development
Organ Morphogenesis
Developmental Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
RNA Biosynthetic Process
Anterior/posterior Pattern Specification
Cell Migration
Regulation Of Binding
Positive Regulation Of Transcription, DNA-templated
Cell Motility
Mesenchymal Cell Development
Cell Differentiation
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Embryonic Nail Plate Morphogenesis
Gene Expression
Central Nervous System Development
Odontogenesis
Mesenchymal Cell Differentiation
Face Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of BMP Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Activation Of Meiosis
Generation Of Neurons
Head Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Signal Transduction
Negative Regulation Of Signaling
Negative Regulation Of Cellular Metabolic Process
Gene Expression
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Signal Transduction
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Nucleobase-containing Compound Metabolic Process
Regulation Of Signaling
Regulation Of Anoikis
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Negative Regulation Of Wnt Signaling Pathway
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of Binding
Positive Regulation Of Gene Expression
Wnt Signaling Pathway
Regulation Of Wnt Signaling Pathway
Negative Regulation Of Protein Binding
Organ Development
Biosynthetic Process
Regulation Of Primitive Erythrocyte Differentiation
Positive Regulation Of Interleukin-13 Biosynthetic Process
Regulation Of DNA Binding
Negative Regulation Of Binding
Regulation Of Metabolic Process
Positive Regulation Of Interleukin-10 Biosynthetic Process
Positive Regulation Of Interleukin-4 Biosynthetic Process
Myeloid Leukocyte Differentiation
Positive Regulation Of Transcription, DNA-templated
Interferon-gamma-mediated Signaling Pathway
Notch Signaling Pathway
Response To Stimulus
Tagcloud
?
122c
2012cb944901
9qh
azoospermia
blimp1
dazl
ddx4
declare
dppa3
envisioned
fam122c
funds
grants
hef
ikbkg
ipsc
ipscs
lin28
poi
poi1
poi2
q26
rbmx
stella
sublines
talents
vasa
xq
znf
Tagcloud (Difference)
?
122c
2012cb944901
9qh
azoospermia
blimp1
dazl
ddx4
declare
dppa3
envisioned
fam122c
funds
grants
hef
ikbkg
ipsc
ipscs
lin28
poi
poi1
poi2
q26
rbmx
stella
sublines
talents
vasa
xq
znf
Tagcloud (Intersection)
?