TLE2 and EMX2

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		TLE2	EMX2
Name		TLE family member 2, transcriptional corepressor	empty spiracles homeobox 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body	Chromatin Nucleus Axon Cell Projection
	Molecular Function	Transcription Corepressor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway	Neuron Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Response To Xenobiotic Stimulus Anterior/posterior Pattern Specification Regulation Of Gene Expression Dentate Gyrus Development Cerebral Cortex Regionalization Cell Proliferation In Forebrain Forebrain Cell Migration Cerebral Cortex Development Neuron Differentiation Forebrain Development Ureter Morphogenesis Stereocilium Bundle Organization
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	Formation of the nephric duct
GWAS		No GWAS studies recorded	Airflow obstruction ( 22837378 ) Celiac disease ( 23936387 ) Chronotype ( 30696823 ) Double-edged eyelids ( 29895819 ) Early cardiac repolarization ( 22683750 ) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828 ) Liver fibrosis (total hepatic collagen content) ( 32953199 ) Low tan response ( 29739929 ) Neuroticism ( 29255261 ) Obesity-related traits ( 23251661 ) Ovarian disease with few adhesions ( 28333195 ) Photic sneeze reflex ( 27182965 ) Pulmonary function in asthmatics ( 23541324 ) Response to quetiapine in schizophrenia ( 29503163 ) Serum uric acid levels ( 29403010 30993211 ) Skin pigmentation ( 30664655 ) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655 ) Urate levels ( 31578528 )
Interacting Genes		16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	5 interacting genes: EIF4E GTF2A1L MEIS1 OTUD6A TLE2
Entrez ID		7089	2018
HPRD ID		03025	02495
Ensembl ID		ENSG00000065717	ENSG00000170370
Uniprot IDs		K7EMK7 Q04725	Q04743
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Developmental Process Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cell Differentiation Animal Organ Development Cell Population Proliferation Nucleus Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding BMP Signaling Pathway Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Odontogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process Positive Regulation Of Biosynthetic Process Face Morphogenesis DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regionalization Midbrain Development Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Animal Organ Morphogenesis Embryonic Nail Plate Morphogenesis Positive Regulation Of BMP Signaling Pathway Tube Morphogenesis Negative Regulation Of Biosynthetic Process	Eukaryotic Initiation Factor 4G Binding MRNA Cap Binding Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Neuron Differentiation Regulation Of Translation At Postsynapse Negative Regulation Of Neuron Differentiation Transcription Factor TFIIA Complex Protein K33-linked Deubiquitination Protein K27-linked Deubiquitination Protein K29-linked Deubiquitination Transcription Regulator Complex Cell Growth Involved In Cardiac Muscle Cell Development