TLE2 and EMX2

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		TLE2	EMX2
Gene Name		transducin-like enhancer of split 2	empty spiracles homeobox 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm	Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding	Protein Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Notch Signaling Pathway Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway	Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebral Cortex Regionalization Cell Proliferation In Forebrain Forebrain Cell Migration Neuron Differentiation Response To Drug Renal System Development
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer truncations of AMER1 destabilize the destruction complex FBXW7 Mutants and NOTCH1 in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes NOTCH1 Intracellular Domain Regulates Transcription deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by WNT in cancer
Drugs
Diseases
GWAS			Airflow obstruction ( 22837378) Cardiac repolarization ( 22683750) Obesity-related traits ( 23251661) Pulmonary function in asthmatics ( 23541324)
Protein-Protein Interactions		16 interactors: BARHL1 EMX2 FOXA3 H3F3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	4 interactors: EIF4E GTF2A1L MEIS1 TLE2
Entrez ID		7089	2018
HPRD ID		03025	02495
Ensembl ID		ENSG00000065717	ENSG00000170370
Uniprot IDs		B4DE62 K7EMK7 Q04725	Q04743
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Multicellular Organismal Development Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process System Development Organ Morphogenesis Developmental Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development RNA Biosynthetic Process Anterior/posterior Pattern Specification Cell Migration Regulation Of Binding Positive Regulation Of Transcription, DNA-templated Cell Motility Mesenchymal Cell Development Cell Differentiation Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Gene Expression Central Nervous System Development Odontogenesis Mesenchymal Cell Differentiation Face Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of BMP Signaling Pathway Nucleobase-containing Compound Metabolic Process Activation Of Meiosis Generation Of Neurons Head Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process	RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Megakaryocyte Development Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Megakaryocyte Differentiation Definitive Hemopoiesis Nuclear-transcribed MRNA Poly(A) Tail Shortening Lens Morphogenesis In Camera-type Eye Organ Development Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Metabolic Process Organ Morphogenesis
Tagcloud ?			bmp cortico demethylase depolarizing differentiative doubled egfp foxg1 h3k27 h3k4m2 hdacs hmtase identities lentivirus lhx2 mix neuron nsc pax6 pulses reprogramme reprogrammed reprogramming sox1 specification teton tgfbeta transgenes trp53
Tagcloud (Difference) ?			bmp cortico demethylase depolarizing differentiative doubled egfp foxg1 h3k27 h3k4m2 hdacs hmtase identities lentivirus lhx2 mix neuron nsc pax6 pulses reprogramme reprogrammed reprogramming sox1 specification teton tgfbeta transgenes trp53
Tagcloud (Intersection) ?