GLB1

Description		galactosidase beta 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Lysosome Vacuole Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-galactosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Galactoside Binding Protein Homodimerization Activity
	Biological Process	Carbohydrate Metabolic Process Glycoprotein Catabolic Process Ganglioside Catabolic Process Galactose Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Keratan Sulfate Proteoglycan Catabolic Process Glycosphingolipid Catabolic Process Response To Cortisone Response To Thyroglobulin Triiodothyronine
Pathways		Keratan sulfate degradation CS/DS degradation MPS IV - Morquio syndrome B (Keratin metabolism) Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation Glycosphingolipid catabolism MPS IV - Morquio syndrome B (CS/DS degradation)
Drugs		Lactose
Diseases		Mucopolysaccharidosis type IV (MPS4), including: Morquio syndrome A (MPS4A); Morquio syndrome B (MPS4B) Galactosialidosis GM1 gangliosidosis
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 33547301) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Atopic dermatitis ( 23042114) Celiac disease ( 22057235) Eosinophil count ( 29403010 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hepatocellular carcinoma ( 21105107) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		11 interacting genes: CSNK2B CTSA DNAJB1 FOS GOLM1 NEU1 PLK1 SLC10A6 SLC30A2 SLC7A1 TK1
Entrez ID		2720
HPRD ID		01975
Ensembl ID		ENSG00000170266
Uniprot IDs		B7Z6Q5 E7EQ29 P16278
PDB IDs		3THC 3THD 3WEZ 3WF0 3WF1 3WF2 3WF3 3WF4
Enriched GO Terms of Interacting Partners?
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