TIMP3 and MMP2

Number of citations of the paper that reports this interaction (PubMedID 7782289)
0

Data Source:
HPRD (in vitro)

		TIMP3	MMP2
Description		TIMP metallopeptidase inhibitor 3	matrix metallopeptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Extracellular Matrix Platelet Dense Granule Lumen Secretory Granule Lumen	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Plasma Membrane Membrane Sarcomere Extracellular Matrix
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Metal Ion Binding	Fibronectin Binding Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Visual Perception Response To Hormone Negative Regulation Of Extracellular Matrix Disassembly Response To Cytokine Negative Regulation Of Proteolysis Negative Regulation Of Membrane Protein Ectodomain Proteolysis	Angiogenesis Ovarian Follicle Development Ovulation From Ovarian Follicle Luteinization Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Response To Oxidative Stress Negative Regulation Of Cell Adhesion Heart Development Female Pregnancy Embryo Implantation Parturition Response To Xenobiotic Stimulus Response To Mechanical Stimulus Peripheral Nervous System Axon Regeneration Response To Activity Cell Migration Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Positive Regulation Of Cell Migration Collagen Catabolic Process Response To Retinoic Acid Response To Cytokine Cellular Response To Reactive Oxygen Species Response To Nicotine Endodermal Cell Differentiation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Response To Estrogen Negative Regulation Of Vasoconstriction Ephrin Receptor Signaling Pathway Macrophage Chemotaxis Positive Regulation Of Smooth Muscle Cell Proliferation Skeletal System Morphogenesis Tissue Remodeling Response To Electrical Stimulus Response To Hyperoxia Face Morphogenesis Bone Trabecula Formation Prostate Gland Epithelium Morphogenesis Trophoblast Cell Migration Cellular Response To Amino Acid Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-1 Cellular Response To Estradiol Stimulus Cellular Response To UV-A Cellular Response To Fluid Shear Stress Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		Platelet degranulation	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		Pimagedine	Marimastat Captopril SC-74020 Halofuginone AE-941 Endostatin Oleandrin
Diseases		Sorsby fundus dystrophy	Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 21665990 23455636) Alzheimer's disease progression score ( 29860282) Metabolite levels ( 23823483) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 31170924)	Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9	40 interacting genes: A2M ACAN BACE1 BCAN CAPN3 CCL7 CCN5 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP REL SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		7078	4313
HPRD ID		01785	00386
Ensembl ID		ENSG00000100234	ENSG00000087245
Uniprot IDs		P35625	P08253
PDB IDs		3CKI	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU 7XGJ 7XJO 8H78
Enriched GO Terms of Interacting Partners?		Endopeptidase Activity Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Extracellular Matrix Disassembly Collagen Metabolic Process Serine-type Endopeptidase Activity Extracellular Matrix Cellular Response To UV-A Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidase Activity Response To Amyloid-beta Response To UV-A Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Endodermal Cell Differentiation Protein Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Ovarian Follicle Development Animal Organ Morphogenesis Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Proteolysis Post-embryonic Eye Morphogenesis Animal Organ Development Cellular Response To UV Extracellular Space Cellular Response To Light Stimulus Hydrolase Activity Cell Migration Ossification Integrin Binding Macromolecule Metabolic Process Cell Motility Response To UV Cellular Response To Radiation Cell Surface Receptor Signaling Pathway Extracellular Region Endochondral Ossification Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation	Extracellular Matrix Extracellular Space Extracellular Region Peptidase Inhibitor Activity Protease Binding Metalloendopeptidase Inhibitor Activity Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Locomotion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Membrane Protein Ectodomain Proteolysis Cell Adhesion Positive Regulation Of Developmental Process Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Response To Hormone Skeletal System Development Regulation Of Apoptotic Process Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Cell Migration Extracellular Matrix Binding Regulation Of Mononuclear Cell Migration Integrin Binding Positive Regulation Of Leukocyte Migration Perineuronal Net Negative Regulation Of Multicellular Organismal Process Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength Response To Carbohydrate Regulation Of Proteolysis Regulation Of Developmental Process Basement Membrane Regulation Of Cell Junction Assembly Regulation Of Anatomical Structure Morphogenesis Cell Motility Extracellular Matrix Structural Constituent Conferring Compression Resistance Developmental Process Golgi Lumen Response To Xenobiotic Stimulus Negative Regulation Of Metallopeptidase Activity Angiogenesis
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