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TIMP3 and ADAM17
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
TIMP3
ADAM17
Description
TIMP metallopeptidase inhibitor 3
ADAM metallopeptidase domain 17
Image
GO Annotations
Cellular Component
Extracellular Region
Basement Membrane
Extracellular Space
Nucleus
Extracellular Matrix
Platelet Dense Granule Lumen
Secretory Granule Lumen
Golgi Membrane
Cytoplasm
Endoplasmic Reticulum Lumen
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Surface
Actin Cytoskeleton
Membrane
Apical Plasma Membrane
Ruffle Membrane
Membrane Raft
Molecular Function
Enzyme Inhibitor Activity
Protein Binding
Metalloendopeptidase Inhibitor Activity
Peptidase Inhibitor Activity
Metal Ion Binding
Endopeptidase Activity
Metalloendopeptidase Activity
Notch Binding
Interleukin-6 Receptor Binding
Integrin Binding
Protein Binding
Peptidase Activity
Metallopeptidase Activity
Hydrolase Activity
SH3 Domain Binding
Cytokine Binding
PDZ Domain Binding
Tumor Necrosis Factor Binding
Metal Ion Binding
Metallodipeptidase Activity
Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
Biological Process
Visual Perception
Response To Hormone
Negative Regulation Of Extracellular Matrix Disassembly
Response To Cytokine
Negative Regulation Of Proteolysis
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Response To Hypoxia
Neutrophil Mediated Immunity
Germinal Center Formation
Production Of Molecular Mediator Involved In Inflammatory Response
Positive Regulation Of Leukocyte Chemotaxis
Proteolysis
Membrane Protein Ectodomain Proteolysis
Cell Adhesion
Epidermal Growth Factor Receptor Signaling Pathway
Notch Signaling Pathway
Notch Receptor Processing
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Positive Regulation Of Signal Transduction
Positive Regulation Of T Cell Chemotaxis
Negative Regulation Of Neuron Projection Development
Protein Processing
Signal Release
B Cell Differentiation
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Lipopolysaccharide
Positive Regulation Of Chemokine Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Mast Cell Apoptotic Process
T Cell Differentiation In Thymus
Cell Adhesion Mediated By Integrin
Wound Healing, Spreading Of Epidermal Cells
Amyloid Precursor Protein Catabolic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Spleen Development
Regulation Of Axon Regeneration
Cell Motility
Defense Response To Gram-positive Bacterium
Cellular Response To High Density Lipoprotein Particle Stimulus
Commissural Neuron Axon Guidance
Negative Regulation Of Cold-induced Thermogenesis
Cytokine Precursor Processing
Signaling Receptor Ligand Precursor Processing
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Vascular Endothelial Cell Proliferation
Regulation Of Neuron Migration
Pathways
Platelet degranulation
Nuclear signaling by ERBB4
Collagen degradation
Signaling by EGFR
Regulated proteolysis of p75NTR
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Release of Hh-Np from the secreting cell
TNF signaling
CD163 mediating an anti-inflammatory response
Growth hormone receptor signaling
Drugs
Pimagedine
(3S)-1-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}pyrrolidine-3-thiol
3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol
4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
(2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE
methyl (1R,2S)-2-(hydroxycarbamoyl)-1-{4-[(2-methylquinolin-4-yl)methoxy]benzyl}cyclopropanecarboxylate
(1S,3R,6S)-4-oxo-6-{4-[(2-phenylquinolin-4-yl)methoxy]phenyl}-5-azaspiro[2.4]heptane-1-carboxylic acid
N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan
(3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
Diseases
Sorsby fundus dystrophy
GWAS
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
20385819
20385826
21665990
23455636
)
Alzheimer's disease progression score (
29860282
)
Metabolite levels (
23823483
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Triglyceride levels (
31170924
)
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Offspring birth weight (
31043758
)
Interacting Genes
8 interacting genes:
ADAM17
EFEMP1
KDR
MMP13
MMP14
MMP2
MMP3
MMP9
13 interacting genes:
DLG1
ERBB4
FHL2
MAD2L1
MAD2L2
NOTCH1
PTPN3
SH3D19
TGFA
TIMP3
TNF
TNFRSF1A
TNFSF11
Entrez ID
7078
6868
HPRD ID
01785
04703
Ensembl ID
ENSG00000100234
ENSG00000151694
Uniprot IDs
P35625
B2RNB2
P78536
PDB IDs
3CKI
1BKC
1ZXC
2A8H
2DDF
2FV5
2FV9
2I47
2M2F
2OI0
3B92
3CKI
3E8R
3EDZ
3EWJ
3G42
3KMC
3KME
3L0T
3L0V
3LE9
3LEA
3LGP
3O64
8CQY
8SNL
8SNN
8SNO
9E6K
Enriched GO Terms of Interacting Partners
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Endopeptidase Activity
Metalloendopeptidase Activity
Collagen Catabolic Process
Metallopeptidase Activity
Extracellular Matrix Disassembly
Collagen Metabolic Process
Serine-type Endopeptidase Activity
Extracellular Matrix
Cellular Response To UV-A
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Peptidase Activity
Response To Amyloid-beta
Response To UV-A
Extracellular Matrix Organization
Extracellular Structure Organization
Enzyme-linked Receptor Protein Signaling Pathway
Endodermal Cell Differentiation
Protein Metabolic Process
Regulation Of Cell Migration
Regulation Of Cell Motility
Ovarian Follicle Development
Animal Organ Morphogenesis
Regulation Of Locomotion
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Proteolysis
Post-embryonic Eye Morphogenesis
Animal Organ Development
Cellular Response To UV
Extracellular Space
Cellular Response To Light Stimulus
Hydrolase Activity
Cell Migration
Ossification
Integrin Binding
Macromolecule Metabolic Process
Cell Motility
Response To UV
Cellular Response To Radiation
Cell Surface Receptor Signaling Pathway
Extracellular Region
Endochondral Ossification
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of ERBB Signaling Pathway
Regulation Of Neuroinflammatory Response
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Embryo Implantation
Anatomical Structure Morphogenesis
Peptidyl-tyrosine Phosphorylation
Regulation Of Membrane Protein Ectodomain Proteolysis
Epithelial Cell Proliferation
Mammary Gland Alveolus Development
Regulation Of Protein Catabolic Process
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Signal Transduction
Negative Regulation Of Extracellular Matrix Organization
Regulation Of Mitotic Cell Cycle
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Mitotic Nuclear Division
Negative Regulation Of Protein Catabolic Process
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Nuclear Division
Regulation Of Endothelial Cell Differentiation
Negative Regulation Of Extracellular Matrix Constituent Secretion
Negative Regulation Of Cell Cycle
Regulation Of MAPK Cascade
Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Catabolic Process
Positive Regulation Of Fever Generation
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Regulation Of Primary Metabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Extracellular Matrix Constituent Secretion
Positive Regulation Of Apoptotic Process Involved In Development
Regulation Of Fever Generation
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of MAPK Cascade
Negative Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Extracellular Matrix Organization
Intracellular Signal Transduction
Protein Localization To Cell Periphery
Establishment Of Centrosome Localization
Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Cell Surface Receptor Signaling Pathway Via STAT
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Heat Generation
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell-cell Adhesion
Regulation Of Macromolecule Metabolic Process
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
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Tagcloud (Intersection)
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