TIMP3 and MMP13

Number of citations of the paper that reports this interaction (PMID 9065415)
55

Data Source:
HPRD (in vitro)

		TIMP3	MMP13
Gene Name		TIMP metallopeptidase inhibitor 3	matrix metallopeptidase 13 (collagenase 3)
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Nucleus Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Protease Binding Protein Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding
	Biological Process	Visual Perception Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Organic Substance	Endochondral Ossification Growth Plate Cartilage Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Bone Mineralization Collagen Catabolic Process Cellular Protein Metabolic Process Bone Morphogenesis
Pathways			Collagen formation Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs			Marimastat 3-Methylpyridine 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide WAY-151693 Hydroxyaminovaline 1-Methyloxy-4-Sulfone-Benzene PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE] TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990)
Protein-Protein Interactions		8 interactors: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9	8 interactors: ADAMTS5 BCAN CCL7 COL2A1 F12 LRP1 MMP14 TIMP3
Entrez ID		7078	4322
HPRD ID		01785	02522
Ensembl ID		ENSG00000100234	ENSG00000137745
Uniprot IDs		P35625	A8K846 G5E971 P45452 Q53H33
PDB IDs		3CKI	1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3ZXH 456C 4A7B 4FU4 4FVL 4G0D 830C
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Endodermal Cell Differentiation Regulation Of Cell Migration Endoderm Formation Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Ossification Proteolysis Positive Regulation Of Cell Migration Endoderm Development Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process Formation Of Primary Germ Layer Protein Metabolic Process Skeletal System Development Locomotion Anatomical Structure Morphogenesis Gastrulation Movement Of Cell Or Subcellular Component Skeletal System Morphogenesis Endochondral Ossification Organ Development Cell Migration Response To Hypoxia Regulation Of Focal Adhesion Assembly Cell Motility Angiogenesis Cellular Response To Amino Acid Stimulus Regulation Of Cell Junction Assembly Anatomical Structure Formation Involved In Morphogenesis Ovarian Follicle Development Embryo Implantation Blood Vessel Morphogenesis Embryo Development Positive Regulation Of Epithelial Cell Migration Endochondral Bone Morphogenesis Single Organism Reproductive Process Cellular Response To Organonitrogen Compound	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endochondral Ossification Response To External Stimulus Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Glycoprotein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Beta-amyloid Clearance Multicellular Organismal Metabolic Process Proteoglycan Metabolic Process Zymogen Activation Response To Organic Substance Factor XII Activation Skeletal System Development Bone Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Fibrinolysis Embryonic Skeletal System Development Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Plasminogen Activation Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Cardiovascular System Development Astrocyte Cell Migration Bone Development Protein Processing Eosinophil Chemotaxis Protein Metabolic Process Eosinophil Migration Chondrocyte Proliferation Cellular Response To Ethanol Response To Stimulus Protein Autoprocessing Limb Bud Formation Plasma Kallikrein-kinin Cascade Skeletal System Morphogenesis Protein O-linked Fucosylation Dermatan Sulfate Biosynthetic Process Ossification Regulation Of Phospholipase A2 Activity
Tagcloud ?		01b74 a375 accomplished antagomir athymic cutaneous immunoblot implement injections intra invasiveness mel melanoma metalloproteinases metastatic mimicking mir mmps ncr nu nucleic overexpressing radial transfection tumoral turn vertical wm1552c wm793b	advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eif3i eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis ogx option proliferative promoted shorter silencing suppressing turn utilized
Tagcloud (Difference) ?		01b74 a375 accomplished antagomir athymic cutaneous immunoblot implement injections intra invasiveness mel melanoma metalloproteinases metastatic mimicking mir mmps ncr nu nucleic overexpressing radial transfection tumoral vertical wm1552c wm793b	advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eif3i eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis ogx option proliferative promoted shorter silencing suppressing utilized
Tagcloud (Intersection) ?		turn