TIMP3 and MMP13

Number of citations of the paper that reports this interaction (PubMedID 9065415)
0

Data Source:
HPRD (in vitro)

		TIMP3	MMP13
Description		TIMP metallopeptidase inhibitor 3	matrix metallopeptidase 13
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Extracellular Matrix Platelet Dense Granule Lumen Secretory Granule Lumen	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Metal Ion Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Visual Perception Response To Hormone Negative Regulation Of Extracellular Matrix Disassembly Response To Cytokine Negative Regulation Of Proteolysis Negative Regulation Of Membrane Protein Ectodomain Proteolysis	Endochondral Ossification Growth Plate Cartilage Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Bone Mineralization Collagen Catabolic Process Bone Morphogenesis Response To Amyloid-beta
Pathways		Platelet degranulation	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures RUNX2 regulates genes involved in cell migration
Drugs		Pimagedine	Marimastat 3-Methylpyridine 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide WAY-151693 Hydroxyaminovaline 4-methoxybenzenesulfinate PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE] Endostatin TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE CTS-1027 BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
Diseases		Sorsby fundus dystrophy	Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 21665990 23455636) Alzheimer's disease progression score ( 29860282) Metabolite levels ( 23823483) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 31170924)	Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Peanut allergy ( 29030101)
Interacting Genes		8 interacting genes: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9	9 interacting genes: ADAMTS5 BCAN CCL7 COL2A1 F12 FBXO7 LRP1 MMP14 TIMP3
Entrez ID		7078	4322
HPRD ID		01785	02522
Ensembl ID		ENSG00000100234	ENSG00000137745
Uniprot IDs		P35625	P45452 Q53H33
PDB IDs		3CKI	1EUB 1FLS 1FM1 1PEX 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3WV1 3WV2 3WV3 3ZXH 456C 4A7B 4FU4 4FVL 4G0D 4JP4 4JPA 4L19 5B5O 5B5P 5BOT 5BOY 5BPA 5UWK 5UWL 5UWM 5UWN 7JU8 830C
Enriched GO Terms of Interacting Partners?		Endopeptidase Activity Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Extracellular Matrix Disassembly Collagen Metabolic Process Serine-type Endopeptidase Activity Extracellular Matrix Cellular Response To UV-A Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidase Activity Response To Amyloid-beta Response To UV-A Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Endodermal Cell Differentiation Protein Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Ovarian Follicle Development Animal Organ Morphogenesis Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Proteolysis Post-embryonic Eye Morphogenesis Animal Organ Development Cellular Response To UV Extracellular Space Cellular Response To Light Stimulus Hydrolase Activity Cell Migration Ossification Integrin Binding Macromolecule Metabolic Process Cell Motility Response To UV Cellular Response To Radiation Cell Surface Receptor Signaling Pathway Extracellular Region Endochondral Ossification Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation	Extracellular Matrix Extracellular Space Head Development Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Regulation Of Extracellular Matrix Disassembly Endochondral Ossification Regulation Of Protein Localization To Membrane Skeletal System Development Zymogen Activation Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Regulation Of Metabolic Process Regulation Of Protein Processing Regulation Of Protein Maturation Fatty Acid-CoA Ligase Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Cellular Response To Genistein Extracellular Matrix Disassembly Negative Regulation Of GDF15-GFRAL Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Extracellular Matrix Organization Bone Development Positive Regulation Of Protein Localization To Cell Periphery Embryonic Skeletal System Morphogenesis Plasma Kallikrein-kinin Cascade Regulation Of Proteolysis Factor XII Activation Positive Regulation Of Protein Localization To Membrane Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Endopeptidase Activity Metalloendopeptidase Activity Basement Membrane Positive Regulation Of Mononuclear Cell Migration Collagen Type II Trimer Positive Regulation Of Phosphatidylcholine Biosynthetic Process Lipoprotein Particle Receptor Binding Golgi Lumen Response To Odorant Lewy Body Core
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