TIMP3

Description		TIMP metallopeptidase inhibitor 3
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Nucleus Extracellular Matrix Platelet Dense Granule Lumen Secretory Granule Lumen
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Visual Perception Response To Hormone Negative Regulation Of Extracellular Matrix Disassembly Response To Cytokine Negative Regulation Of Proteolysis Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Pathways		Platelet degranulation
Drugs		Pimagedine
Diseases		Sorsby fundus dystrophy
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 21665990 23455636) Alzheimer's disease progression score ( 29860282) Metabolite levels ( 23823483) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 31170924)
Interacting Genes		8 interacting genes: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9
Entrez ID		7078
HPRD ID		01785
Ensembl ID		ENSG00000100234
Uniprot IDs		P35625
PDB IDs		3CKI
Enriched GO Terms of Interacting Partners?		Endopeptidase Activity Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Extracellular Matrix Disassembly Collagen Metabolic Process Serine-type Endopeptidase Activity Extracellular Matrix Cellular Response To UV-A Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Peptidase Activity Response To Amyloid-beta Response To UV-A Extracellular Matrix Organization Extracellular Structure Organization Enzyme-linked Receptor Protein Signaling Pathway Endodermal Cell Differentiation Protein Metabolic Process Regulation Of Cell Migration Regulation Of Cell Motility Ovarian Follicle Development Animal Organ Morphogenesis Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Proteolysis Post-embryonic Eye Morphogenesis Animal Organ Development Cellular Response To UV Extracellular Space Cellular Response To Light Stimulus Hydrolase Activity Cell Migration Ossification Integrin Binding Macromolecule Metabolic Process Cell Motility Response To UV Cellular Response To Radiation Cell Surface Receptor Signaling Pathway Extracellular Region Endochondral Ossification Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Neuroinflammatory Response Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Embryo Implantation Anatomical Structure Morphogenesis Peptidyl-tyrosine Phosphorylation
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