TIMP3

Gene Name		TIMP metallopeptidase inhibitor 3
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Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Nucleus Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Protein Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Visual Perception Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Organic Substance
Pathways
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990)
Protein-protein Interactions		8 interactors: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9
Entrez ID		7078
HPRD ID		01785
Ensembl ID		ENSG00000100234
Uniprot IDs		P35625
PDB IDs		3CKI
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Endodermal Cell Differentiation Regulation Of Cell Migration Endoderm Formation Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Ossification Proteolysis Positive Regulation Of Cell Migration Endoderm Development Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process Formation Of Primary Germ Layer Protein Metabolic Process Skeletal System Development Locomotion Anatomical Structure Morphogenesis Gastrulation Movement Of Cell Or Subcellular Component Skeletal System Morphogenesis Endochondral Ossification Organ Development Cell Migration Response To Hypoxia Regulation Of Focal Adhesion Assembly Cell Motility Angiogenesis Cellular Response To Amino Acid Stimulus Regulation Of Cell Junction Assembly Anatomical Structure Formation Involved In Morphogenesis Ovarian Follicle Development Embryo Implantation Blood Vessel Morphogenesis Embryo Development Positive Regulation Of Epithelial Cell Migration Endochondral Bone Morphogenesis Single Organism Reproductive Process Cellular Response To Organonitrogen Compound
Tagcloud ?		01b74 a375 accomplished antagomir athymic cutaneous immunoblot implement injections intra invasiveness mel melanoma metalloproteinases metastatic mimicking mir mmps ncr nu nucleic overexpressing radial transfection tumoral turn vertical wm1552c wm793b