TIMP3 and EFEMP1

Number of citations of the paper that reports this interaction (PMID 15123717)
19

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		TIMP3	EFEMP1
Gene Name		TIMP metallopeptidase inhibitor 3	EGF containing fibulin-like extracellular matrix protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Nucleus Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Protein Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Epidermal Growth Factor-activated Receptor Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity
	Biological Process	Visual Perception Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Organic Substance	Regulation Of Transcription, DNA-templated Epidermal Growth Factor Receptor Signaling Pathway Visual Perception Peptidyl-tyrosine Phosphorylation Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation
Pathways			Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990)	Amyotrophic lateral sclerosis ( 19451621) Height ( 20881960 19396169 19893584 23563607 18391951 18391952 20397748 20189936)
Protein-Protein Interactions		8 interactors: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9	17 interactors: ARAF ATN1 ATXN7 BAG6 CACNA1A GFI1B KHDRBS1 NOS3 RAF1 RERE RIC8A SGTA SOCS6 TIMP3 TNIP1 TRAF2 TXNDC5
Entrez ID		7078	2202
HPRD ID		01785	03331
Ensembl ID		ENSG00000100234	ENSG00000115380
Uniprot IDs		P35625	B2R6M6 Q12805
PDB IDs		3CKI
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Endodermal Cell Differentiation Regulation Of Cell Migration Endoderm Formation Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Ossification Proteolysis Positive Regulation Of Cell Migration Endoderm Development Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process Formation Of Primary Germ Layer Protein Metabolic Process Skeletal System Development Locomotion Anatomical Structure Morphogenesis Gastrulation Movement Of Cell Or Subcellular Component Skeletal System Morphogenesis Endochondral Ossification Organ Development Cell Migration Response To Hypoxia Regulation Of Focal Adhesion Assembly Cell Motility Angiogenesis Cellular Response To Amino Acid Stimulus Regulation Of Cell Junction Assembly Anatomical Structure Formation Involved In Morphogenesis Ovarian Follicle Development Embryo Implantation Blood Vessel Morphogenesis Embryo Development Positive Regulation Of Epithelial Cell Migration Endochondral Bone Morphogenesis Single Organism Reproductive Process Cellular Response To Organonitrogen Compound	Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Signaling Regulation Of Cellular Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Lyase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Regulation Of Nitrogen Compound Metabolic Process Death Chromatin Modification Negative Regulation Of Signal Transduction Cell-cell Adhesion Involved In Gastrulation Cerebellar Molecular Layer Development Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Death-inducing Signaling Complex Assembly Cellular Metabolic Process Signal Transduction Regulation Of Cyclase Activity Negative Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Signal Transduction Response To Stress Chromatin Organization Positive Regulation Of Peptidyl-serine Phosphorylation Vestibular Nucleus Development Smooth Muscle Hyperplasia Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Proteolysis Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Protein Processing
Tagcloud ?		01b74 a375 accomplished antagomir athymic cutaneous immunoblot implement injections intra invasiveness mel melanoma metalloproteinases metastatic mimicking mir mmps ncr nu nucleic overexpressing radial transfection tumoral turn vertical wm1552c wm793b	aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation
Tagcloud (Difference) ?		01b74 a375 accomplished antagomir athymic cutaneous immunoblot implement injections intra invasiveness mel melanoma metalloproteinases metastatic mimicking mir mmps ncr nu nucleic overexpressing radial transfection tumoral turn vertical wm1552c wm793b	aberrant aza chip dac deacetylase deoxycytidine depth downregulation fibulin gc h3 histone immunoprecipitation invasion k9 loci markedly metastasis methylation methyltransferase modification node paired rapidly reactivated silenced silencing trichostatin trimethylation
Tagcloud (Intersection) ?