TIMP3 and MMP3

Number of citations of the paper that reports this interaction (PMID 11827795)
6

Data Source:
HPRD (in vitro, in vivo)

		TIMP3	MMP3
Gene Name		TIMP metallopeptidase inhibitor 3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)
Image
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Nucleus Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Mitochondrion Cytosol
	Molecular Function	Protease Binding Protein Binding Metalloendopeptidase Inhibitor Activity Metal Ion Binding	Endopeptidase Activity Metalloendopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Visual Perception Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Organic Substance	Proteolysis Negative Regulation Of Hydrogen Peroxide Metabolic Process Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process Positive Regulation Of Protein Oligomerization Negative Regulation Of Protein Kinase B Signaling Cellular Response To Amino Acid Stimulus Cellular Response To Nitric Oxide Positive Regulation Of Oxidative Stress-induced Cell Death
Pathways			Signaling by GPCR EGFR Transactivation by Gastrin Collagen formation Collagen degradation Gastrin-CREB signalling pathway via PKC and MAPK Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs			Marimastat N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide 3-Methylpyridine A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid Hydroxyaminovaline 1-Methyloxy-4-Sulfone-Benzene 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide R-2-{[4\'-Methoxy-(1,1\'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID [2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCARBAMOYL)-1-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER 2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide 3-[(4\'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990)	Alzheimer's disease ( 22832961)
Protein-Protein Interactions		8 interactors: ADAM17 EFEMP1 KDR MMP13 MMP14 MMP2 MMP3 MMP9	18 interactors: ACAN BCAN CCL13 CCL2 CCL7 CCL8 DCN HAPLN1 IGFBP3 MEOX2 PLG SERPINE1 SPOCK1 SPOCK3 SPP1 TIMP1 TIMP3 TNFSF11
Entrez ID		7078	4314
HPRD ID		01785	01703
Ensembl ID		ENSG00000100234	ENSG00000149968
Uniprot IDs		P35625	P08254
PDB IDs		3CKI	1B3D 1B8Y 1BIW 1BM6 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1M1W 1OO9 1QIA 1QIC 1SLM 1SLN 1UEA 1UMS 1UMT 1USN 2D1O 2JNP 2JT5 2JT6 2SRT 2USN 3OHL 3OHO 3USN 4DPE 4G9L 4JA1
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Endodermal Cell Differentiation Regulation Of Cell Migration Endoderm Formation Regulation Of Cell Motility Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Ossification Proteolysis Positive Regulation Of Cell Migration Endoderm Development Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Catabolic Process Formation Of Primary Germ Layer Protein Metabolic Process Skeletal System Development Locomotion Anatomical Structure Morphogenesis Gastrulation Movement Of Cell Or Subcellular Component Skeletal System Morphogenesis Endochondral Ossification Organ Development Cell Migration Response To Hypoxia Regulation Of Focal Adhesion Assembly Cell Motility Angiogenesis Cellular Response To Amino Acid Stimulus Regulation Of Cell Junction Assembly Anatomical Structure Formation Involved In Morphogenesis Ovarian Follicle Development Embryo Implantation Blood Vessel Morphogenesis Embryo Development Positive Regulation Of Epithelial Cell Migration Endochondral Bone Morphogenesis Single Organism Reproductive Process Cellular Response To Organonitrogen Compound	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Cell Chemotaxis Leukocyte Migration Leukocyte Chemotaxis Cell Migration Granulocyte Chemotaxis Cell Motility Monocyte Chemotaxis Proteoglycan Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Locomotion Calcium Ion Homeostasis Chemotaxis Regulation Of Cell Adhesion Negative Regulation Of Proteolysis Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Processing Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Glycosaminoglycan Metabolic Process Regulation Of Endopeptidase Activity Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Chondroitin Sulfate Metabolic Process Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Peptidase Activity Inflammatory Response Regulation Of Cell-substrate Adhesion Developmental Process Negative Regulation Of Cell Migration Eosinophil Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Cell Motility Negative Regulation Of Cellular Protein Metabolic Process Metal Ion Homeostasis Regulation Of Catalytic Activity Platelet Degranulation Eosinophil Migration Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Negative Regulation Of Cellular Component Movement Response To External Stimulus Negative Regulation Of Fibrinolysis Positive Regulation Of Monocyte Chemotaxis Dermatan Sulfate Biosynthetic Process Negative Regulation Of Locomotion
Tagcloud ?		01b74 a375 accomplished antagomir athymic cutaneous immunoblot implement injections intra invasiveness mel melanoma metalloproteinases metastatic mimicking mir mmps ncr nu nucleic overexpressing radial transfection tumoral turn vertical wm1552c wm793b	6j adp articular blotting c57bl chondrocyte chondrocytes degeneration eicosapentaenoic epa inc intra metalloproteinases mmp13 mmps nitroprusside oa orthop orthopaedic osteoarthritis periodicals poly polyunsaturated reduces res ribose snp society wiley
Tagcloud (Difference) ?		01b74 a375 accomplished antagomir athymic cutaneous immunoblot implement injections invasiveness mel melanoma metastatic mimicking mir ncr nu nucleic overexpressing radial transfection tumoral turn vertical wm1552c wm793b	6j adp articular blotting c57bl chondrocyte chondrocytes degeneration eicosapentaenoic epa inc mmp13 nitroprusside oa orthop orthopaedic osteoarthritis periodicals poly polyunsaturated reduces res ribose snp society wiley
Tagcloud (Intersection) ?		intra metalloproteinases mmps